{"doi":"10.3390/cells7070071","title":"Centrosome Remodelling in Evolution","abstract":"<jats:p>The centrosome is the major microtubule organizing centre (MTOC) in animal cells. The canonical centrosome is composed of two centrioles surrounded by a pericentriolar matrix (PCM). In contrast, yeasts and amoebozoa have lost centrioles and possess acentriolar centrosomes—called the spindle pole body (SPB) and the nucleus-associated body (NAB), respectively. Despite the difference in their structures, centriolar centrosomes and SPBs not only share components but also common biogenesis regulators. In this review, we focus on the SPB and speculate how its structures evolved from the ancestral centrosome. Phylogenetic distribution of molecular components suggests that yeasts gained specific SPB components upon loss of centrioles but maintained PCM components associated with the structure. It is possible that the PCM structure remained even after centrosome remodelling due to its indispensable function to nucleate microtubules. We propose that the yeast SPB has been formed by a step-wise process; (1) an SPB-like precursor structure appeared on the ancestral centriolar centrosome; (2) it interacted with the PCM and the nuclear envelope; and (3) it replaced the roles of centrioles. Acentriolar centrosomes should continue to be a great model to understand how centrosomes evolved and how centrosome biogenesis is regulated.</jats:p>","journal":"Cells","year":2018,"id":588148,"datarank":1.7779233452820258,"base_score":4.110873864173311,"endowment":4.110873864173311,"self_citation_contribution":0.6166310796259968,"citation_network_contribution":1.161292265656029,"self_endowment_contribution":0.6166310796259968,"citer_contribution":1.161292265656029,"corpus_percentile":null,"corpus_rank":null,"citation_count":60,"citer_count":59,"citers_with_citation_signal":50,"citers_with_endowment":50,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1504560,"name":"Mónica Bettencourt-Dias","orcid":null,"position":1,"is_corresponding":false},{"id":573487,"name":"Daisuke Ito","orcid":"0000-0003-1924-3849","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Centrosome Remodelling in Evolution","abstract":"<jats:p>The centrosome is the major microtubule organizing centre (MTOC) in animal cells. The canonical centrosome is composed of two centrioles surrounded by a pericentriolar matrix (PCM). In contrast, yeasts and amoebozoa have lost centrioles and possess acentriolar centrosomes—called the spindle pole body (SPB) and the nucleus-associated body (NAB), respectively. Despite the difference in their structures, centriolar centrosomes and SPBs not only share components but also common biogenesis regulators. In this review, we focus on the SPB and speculate how its structures evolved from the ancestral centrosome. Phylogenetic distribution of molecular components suggests that yeasts gained specific SPB components upon loss of centrioles but maintained PCM components associated with the structure. It is possible that the PCM structure remained even after centrosome remodelling due to its indispensable function to nucleate microtubules. We propose that the yeast SPB has been formed by a step-wise process; (1) an SPB-like precursor structure appeared on the ancestral centriolar centrosome; (2) it interacted with the PCM and the nuclear envelope; and (3) it replaced the roles of centrioles. Acentriolar centrosomes should continue to be a great model to understand how centrosomes evolved and how centrosome biogenesis is regulated.</jats:p>","is_dataset_classified":null,"base_score":4.110873864173311,"endowment":4.110873864173311,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29986477","pmcid":"PMC6070874","openalex_id":"https://openalex.org/W2876005425","authors":[],"funders":[{"funder_name":"Human Frontier Science Program","grant_id":"LT000344/2013","title":null},{"funder_name":"European Research Council","grant_id":"CoG683528","title":null},{"funder_name":"Fundação para a Ciência e a Tecnologia","grant_id":"PTDC/BIM-ONC/6858/2014","title":"\"Length matters: Causes and consequences of centriole length deregulation in cancer\""},{"funder_name":"Uehara Memorial Foundation","grant_id":"Postdoctoral fellowship","title":null}],"total_grants":4,"fwci":3.415,"citation_percentile":0.9326415,"influential_citations":7,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":14},{"year":2020,"count":8},{"year":2021,"count":9},{"year":2022,"count":10},{"year":2023,"count":5},{"year":2024,"count":8},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2073-4409/7/7/71/pdf?version=1530887043","host_type":"journal"},{"url":"https://www.mdpi.com/2073-4409/7/7/71/pdf?version=1530887043","host_type":"GOLD"},{"url":"https://www.mdpi.com/2073-4409/7/7/71/pdf?version=1530887043","host_type":"publisher"},{"url":"https://www.mdpi.com/2073-4409/7/7/71/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/cells7070071","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29986477","host_type":"repository"},{"url":"https://doaj.org/article/9fd23361df3f4cd79a10a730d093b58e","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6070874","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6070874","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6070874?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.3390/cells7070071","host_type":""},{"url":"https://dx.doi.org/10.3390/cells7070071","host_type":""}],"fields_of_study":["Microtubule and mitosis dynamics","Chromosomal and Genetic Variations","Protist diversity and phylogeny","Medicine","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Centrosome","Cell biology","Biology","Genetics","Gene","Cell cycle","Evolution","Spindle Pole Body","Centriole","Spb","Pcm","QH573-671","Review","Cytology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-19T08:47:40.166984Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}