{"doi":"10.3390/cells14151157","title":"Pilot Study of [11C]HY-2-15: A Mixed Alpha-Synuclein and Tau PET Radiotracer","abstract":"A novel brain positron emission tomography (PET) radioligand, [11C]HY-2-15, has potential for imaging alpha-synuclein aggregations in multiple system atrophy and misfolded tau proteins in tauopathies, based on its high binding affinity in disease brain tissue homogenates. Here, we demonstrate that [3H]HY-2-15 has the capability to bind to aggregated alpha-synuclein in multiple system atrophy brain and tau aggregations in progressive supranuclear palsy and corticobasal degeneration brain tissues via in vitro autoradiography study. A first-in-human pilot multicenter clinical study recruited a total of 10 subjects including healthy controls and patients with Parkinson’s disease, multiple system atrophy, or progressive supranuclear palsy. The study revealed that [11C]HY-2-15 has a relatively higher specific uptake in the pallidum and midbrain of patients with progressive supranuclear palsy. Total-body scans performed on the PennPET Explorer showed the radiotracer was cleared by renal excretion. However, the rapid metabolism and low brain uptake resulted in a limited signal of [11C]HY-2-15 in brain.","journal":"Cells","year":2025,"id":526373,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9596,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1037734,"name":"Dinahlee Saturnino Guarino","orcid":"0009-0003-3841-1825","position":1,"is_corresponding":false},{"id":405336,"name":"Anthony J. Young","orcid":"0000-0003-3209-1034","position":2,"is_corresponding":false},{"id":246445,"name":"Andrew Siderowf","orcid":"0000-0002-1750-7698","position":3,"is_corresponding":false},{"id":230030,"name":"Ilya M. Nasrallah","orcid":"0000-0003-2346-7562","position":4,"is_corresponding":false},{"id":720727,"name":"Alexander Schmitz","orcid":"0009-0009-6862-6679","position":5,"is_corresponding":false},{"id":1402494,"name":"C. Ramón García","orcid":null,"position":6,"is_corresponding":false},{"id":931960,"name":"Ho Young Kim","orcid":"0000-0003-4391-9642","position":7,"is_corresponding":false},{"id":405343,"name":"Erin K. Schubert","orcid":"0000-0002-1039-6403","position":8,"is_corresponding":false},{"id":405344,"name":"Hsiaoju Lee","orcid":"0000-0001-9082-8618","position":9,"is_corresponding":false},{"id":52686,"name":"Joel S. Perlmutter","orcid":"0000-0003-3263-8917","position":10,"is_corresponding":false},{"id":323335,"name":"Robert H. Mach","orcid":"0000-0002-7645-2869","position":11,"is_corresponding":false},{"id":323331,"name":"Chia‐Ju Hsieh","orcid":"0000-0002-2833-7727","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T02:50:30.402772Z","pmid":"40801590","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}