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In this review, we concentrate on several key areas: the ultrastructure of axons, the mechanisms of axonal degeneration in ALS, the impact of impaired axonal transport on disease progression in ALS, and the potential for axonal regeneration within the central nervous system (CNS). Our objective is to achieve a more holistic and profound understanding of the multifaceted role that axons play in ALS, thereby offering a more intricate and refined perspective on targeted axonal therapeutic interventions.</jats:p>","journal":"Cells","year":2024,"id":644449,"datarank":0.3264082774935539,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.03452175513525687,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.03452175513525687,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":6,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1677432,"name":"Shuchang Lv","orcid":null,"position":1,"is_corresponding":false},{"id":1677434,"name":"Jinmeng Liu","orcid":"0000-0002-6041-2723","position":2,"is_corresponding":false},{"id":476953,"name":"Yingjun Guan","orcid":"0000-0002-9578-0497","position":3,"is_corresponding":false},{"id":1677435,"name":"Chunjie Xu","orcid":null,"position":4,"is_corresponding":false},{"id":1038448,"name":"Xiaonan Ma","orcid":"0000-0002-2474-6507","position":5,"is_corresponding":false},{"id":1094042,"name":"Mu Li","orcid":"0000-0001-9871-7488","position":6,"is_corresponding":false},{"id":451338,"name":"Xue Bai","orcid":"0000-0002-5973-0353","position":7,"is_corresponding":false},{"id":1649813,"name":"Kexin Liu","orcid":null,"position":8,"is_corresponding":false},{"id":417989,"name":"Haoyun Zhang","orcid":"0000-0001-9729-0849","position":9,"is_corresponding":false},{"id":1677438,"name":"Qiupeng Yan","orcid":null,"position":10,"is_corresponding":false},{"id":1002868,"name":"Fenghua Zhou","orcid":"0000-0002-0431-9532","position":11,"is_corresponding":false},{"id":1046078,"name":"Yanchun Chen","orcid":"0000-0003-4740-9228","position":12,"is_corresponding":false},{"id":322847,"name":"Xiaosu Chen","orcid":"0000-0001-9424-2219","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Exploring the Role of Axons in ALS from Multiple Perspectives","abstract":"<jats:p>Amyotrophic lateral sclerosis (ALS), commonly known as motor neuron disease, is a neurodegenerative disorder characterized by the progressive degeneration of both upper and lower motor neurons. This pathological process results in muscle weakness and can culminate in paralysis. To date, the precise etiology of ALS remains unclear. However, a burgeoning body of research indicates that axonal dysfunction is a pivotal element in the pathogenesis of ALS and significantly influences the progression of disease. Dysfunction of axons in ALS can result in impediments to nerve impulse transmission, leading to motor impairment, muscle atrophy, and other associated complications that severely compromise patients’ quality of life and survival prognosis. In this review, we concentrate on several key areas: the ultrastructure of axons, the mechanisms of axonal degeneration in ALS, the impact of impaired axonal transport on disease progression in ALS, and the potential for axonal regeneration within the central nervous system (CNS). Our objective is to achieve a more holistic and profound understanding of the multifaceted role that axons play in ALS, thereby offering a more intricate and refined perspective on targeted axonal therapeutic interventions.</jats:p>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39768167","pmcid":"PMC11674045","openalex_id":"https://openalex.org/W4405475223","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"82271483","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"ZR2024MH112","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"ZR2024QH628","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"2023YX036","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"2022YX043","title":null},{"funder_name":"Shandong Province Natural Science Foundation of China","grant_id":"ZR2024MH112; ZR2024QH628","title":null},{"funder_name":"Weifang Science and Technology Development Plan Project","grant_id":"2023YX036; 2022YX043","title":null}],"total_grants":7,"fwci":1.655,"citation_percentile":0.85237281,"influential_citations":0,"citation_trend":[{"year":2025,"count":6}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2073-4409/13/24/2076/pdf?version=1734401904","host_type":"journal"},{"url":"https://www.mdpi.com/2073-4409/13/24/2076/pdf?version=1734401904","host_type":"publisher"},{"url":"https://www.mdpi.com/2073-4409/13/24/2076/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/cells13242076","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39768167","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11674045","host_type":"repository"},{"url":"https://doaj.org/article/74ca2c0e7af749cabfe31bc381afd0a2","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11674045/pdf/cells-13-02076.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11674045","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11674045?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Amyotrophic Lateral Sclerosis Research","Neurogenetic and Muscular Disorders Research","Histone Deacetylase Inhibitors Research","Humans","Amyotrophic Lateral Sclerosis","Axons","Animals","Axonal Transport","Motor Neurons","Disease Progression"],"mesh_terms":["Amyotrophic Lateral Sclerosis","Animals","Axons","Axonal Transport","Humans","Motor Neurons","Disease Progression"],"keywords":["Amyotrophic lateral sclerosis","Neuroscience","Axonal degeneration","Motor neuron","Degeneration (medical)","Medicine","Disease","Paralysis","Weakness","Atrophy","Axoplasmic transport","Pathogenesis","Muscle atrophy","Pathology","Biology","Anatomy","Surgery","Therapy","Axon Degeneration","Axon regeneration","Axon Transport"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T01:11:23.240053Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}