{"doi":"10.3390/cells13100823","title":"Glioblastoma Phagocytic Cell Death: Balancing the Opportunities for Therapeutic Manipulation","abstract":"Macrophages and microglia are professional phagocytes that sense and migrate toward \"eat-me\" signals. The role of phagocytic cells is to maintain homeostasis by engulfing senescent or apoptotic cells, debris, and abnormally aggregated macromolecules. Usually, dying cells send out \"find-me\" signals, facilitating the recruitment of phagocytes. Healthy cells can also promote or inhibit the phagocytosis phenomenon of macrophages and microglia by tuning the balance between \"eat-me\" and \"don't-eat-me\" signals at different stages in their lifespan, while the \"don't-eat-me\" signals are often hijacked by tumor cells as a mechanism of immune evasion. Using a combination of bioinformatic analysis and spatial profiling, we delineate the balance of the \"don't-eat-me\" CD47/SIRPα and \"eat-me\" CALR/STC1 ligand-receptor interactions to guide therapeutic strategies that are being developed for glioblastoma sequestered in the central nervous system (CNS).","journal":"Cells","year":2024,"id":453050,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9502,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":417851,"name":"Shashwat Tripathi","orcid":"0000-0001-8172-7532","position":1,"is_corresponding":false},{"id":660545,"name":"Hinda Najem","orcid":"0000-0003-4432-9708","position":2,"is_corresponding":false},{"id":69838,"name":"Daniel J. Brat","orcid":"0000-0002-0633-6563","position":3,"is_corresponding":false},{"id":242017,"name":"Rimas V. Lukas","orcid":"0000-0002-9352-5396","position":4,"is_corresponding":false},{"id":305717,"name":"Peng Zhang","orcid":"0000-0001-9856-7571","position":5,"is_corresponding":false},{"id":271525,"name":"Amy B. Heimberger","orcid":"0000-0002-9970-8695","position":6,"is_corresponding":false},{"id":1049691,"name":"Ruochen Du","orcid":"0000-0002-0580-5196","position":0,"is_corresponding":true}],"reference_count":86,"raw_metadata":null,"created_at":"2026-07-19T02:02:58.784290Z","pmid":"38786045","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}