{"doi":"10.3390/cells13010092","title":"Increased Collagen I/Collagen III Ratio Is Associated with Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse","abstract":"Background: The increase in the collagen I (COL I)/COL III ratio enhances vessel wall stiffness and renders vessels less resistant to blood flow and pressure changes. Activated microglia enhance inflammation-induced fibrosis. Hypotheses: The COL I/COL III ratio in human and mouse brain arteriovenous malformations (bAVMs) is associated with bAVM hemorrhage, and the depletion of microglia decreases the COL I/COL III ratio and hemorrhage. Method: COL I, COL III, and hemorrhages were analyzed in 12 human bAVMs and 6 control brains, and mouse bAVMs induced in three mouse lines with activin receptor-like kinase 1 (n = 7) or endoglin (n = 7) deleted in the endothelial cells or brain focally (n = 5). The controls for the mouse study were no-gene-deleted litter mates. Mouse bAVMs were used to test the relationships between the Col I/Col III ratio and hemorrhage and whether the transient depletion of microglia reduces the Col I/Col III ratio and hemorrhage. Results: The COL I/COL III ratio was higher in the human and mouse bAVMs than in controls. The microhemorrhage in mouse bAVMs was positively correlated with the Col I/Col III ratio. Transient depletion of microglia reduced the Col I/Col III ratio and microhemorrhage. Conclusions: The COL I/COL III ratio in the bAVMs was associated with bAVM hemorrhage. The depletion of microglia reduced the bAVM Col I/Col III ratio and hemorrhage.","journal":"Cells","year":2024,"id":437558,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9596,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":945783,"name":"Joana Schuerger","orcid":null,"position":1,"is_corresponding":false},{"id":672543,"name":"Xiaonan Zhu","orcid":"0000-0002-9226-8201","position":2,"is_corresponding":false},{"id":305524,"name":"Chaoliang Tang","orcid":"0000-0002-1936-028X","position":3,"is_corresponding":false},{"id":1171884,"name":"Li Ma","orcid":"0000-0003-0894-7867","position":4,"is_corresponding":false},{"id":965723,"name":"Alka Yadav","orcid":"0009-0003-8766-2671","position":5,"is_corresponding":false},{"id":1171885,"name":"Rich Liang","orcid":"0000-0002-4072-2396","position":6,"is_corresponding":false},{"id":1172252,"name":"Kelly Press","orcid":null,"position":7,"is_corresponding":false},{"id":5389,"name":"Shantel Weinsheimer","orcid":"0000-0001-7486-9110","position":8,"is_corresponding":false},{"id":1171826,"name":"Annika Schmidt","orcid":null,"position":9,"is_corresponding":false},{"id":1067126,"name":"Calvin Wang","orcid":null,"position":10,"is_corresponding":false},{"id":1179614,"name":"Abinav Sekhar","orcid":null,"position":11,"is_corresponding":false},{"id":364176,"name":"Jeffrey Nelson","orcid":"0000-0002-0219-473X","position":12,"is_corresponding":false},{"id":249214,"name":"Helen Kim","orcid":"0000-0002-1937-354X","position":13,"is_corresponding":false},{"id":308603,"name":"Hua Su","orcid":"0000-0003-1566-9877","position":14,"is_corresponding":false},{"id":945297,"name":"Zahra Shabani","orcid":"0000-0003-4995-3024","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T02:00:34.490087Z","pmid":"38201296","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}