{"doi":"10.3390/cells11060944","title":"Microbial Metabolite Regulation of Epithelial Cell-Cell Interactions and Barrier Function","abstract":"Epithelial cells that line tissues such as the intestine serve as the primary barrier to the outside world. Epithelia provide selective permeability in the presence of a large constellation of microbes, termed the microbiota. Recent studies have revealed that the symbiotic relationship between the healthy host and the microbiota includes the regulation of cell-cell interactions at the level of epithelial tight junctions. The most recent findings have identified multiple microbial-derived metabolites that influence intracellular signaling pathways which elicit activities at the epithelial apical junction complex. Here, we review recent findings that place microbiota-derived metabolites as primary regulators of epithelial cell-cell interactions and ultimately mucosal permeability in health and disease.","journal":"Cells","year":2022,"id":238096,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":56,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9488,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":662139,"name":"Alexander S. Dowdell","orcid":"0000-0002-0513-6623","position":1,"is_corresponding":false},{"id":233314,"name":"J. Scott Lee","orcid":"0000-0001-7151-9828","position":2,"is_corresponding":false},{"id":233316,"name":"Sean P. Colgan","orcid":"0000-0003-0431-8887","position":3,"is_corresponding":false},{"id":669481,"name":"Alfredo Ornelas","orcid":"0000-0002-6773-6691","position":0,"is_corresponding":true}],"reference_count":225,"raw_metadata":null,"created_at":"2026-07-19T00:22:26.932537Z","pmid":"35326394","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}