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Furthermore, it is now clear that STIM1 may inhibit Ca2+ currents mediated by L-type Ca2+ channels. Interestingly, STIM1 also interacts with some intracellular channels and transporters, including nuclear and lysosomal ionic proteins, thus orchestrating organellar Ca2+ homeostasis. STIM1 and its partners/effectors are significantly modulated in diverse acute and chronic neurodegenerative conditions. This highlights the importance of further disclosing their cellular functions as they might represent promising molecular targets for neuroprotection.</jats:p>","journal":"Cells","year":2021,"id":648600,"datarank":0.6198193913541302,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.2470833938859301,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.2470833938859301,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":11,"citers_with_citation_signal":10,"citers_with_endowment":10,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1690404,"name":"Daniele La Russa","orcid":"0000-0003-1887-2854","position":1,"is_corresponding":false},{"id":1690405,"name":"Cristina Franco","orcid":null,"position":2,"is_corresponding":false},{"id":1690406,"name":"Antonio Vinciguerra","orcid":null,"position":3,"is_corresponding":false},{"id":1690407,"name":"Diana Amantea","orcid":"0000-0002-7513-3495","position":4,"is_corresponding":false},{"id":1690408,"name":"Agnese Secondo","orcid":"0000-0001-5054-4098","position":5,"is_corresponding":false},{"id":1690403,"name":"Valentina Tedeschi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Plasma Membrane and Organellar Targets of STIM1 for Intracellular Calcium Handling in Health and Neurodegenerative Diseases","abstract":"<jats:p>Located at the level of the endoplasmic reticulum (ER) membrane, stromal interacting molecule 1 (STIM1) undergoes a complex conformational rearrangement after depletion of ER luminal Ca2+. 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