{"doi":"10.3390/cells10051044","title":"The Effect and Regulatory Mechanism of High Mobility Group Box-1 Protein on Immune Cells in Inflammatory Diseases","abstract":"<jats:p>High mobility group box-1 protein (HMGB1), a member of the high mobility group protein superfamily, is an abundant and ubiquitously expressed nuclear protein. Intracellular HMGB1 is released by immune and necrotic cells and secreted HMGB1 activates a range of immune cells, contributing to the excessive release of inflammatory cytokines and promoting processes such as cell migration and adhesion. Moreover, HMGB1 is a typical damage-associated molecular pattern molecule that participates in various inflammatory and immune responses. In these ways, it plays a critical role in the pathophysiology of inflammatory diseases. Herein, we review the effects of HMGB1 on various immune cell types and describe the molecular mechanisms by which it contributes to the development of inflammatory disorders. Finally, we address the therapeutic potential of targeting HMGB1.</jats:p>","journal":"Cells","year":2021,"id":654201,"datarank":0.6515708132780527,"base_score":4.343805421853684,"endowment":4.343805421853684,"self_citation_contribution":0.6515708132780527,"citation_network_contribution":0.0,"self_endowment_contribution":0.6515708132780527,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":76,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":196364,"name":"Man Huang","orcid":"0000-0002-0842-2254","position":1,"is_corresponding":false},{"id":1707304,"name":"Yong-ming Yao","orcid":null,"position":2,"is_corresponding":false},{"id":364328,"name":"Yun Ge","orcid":"0000-0001-5788-4204","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Effect and Regulatory Mechanism of High Mobility Group Box-1 Protein on Immune Cells in Inflammatory Diseases","abstract":"<jats:p>High mobility group box-1 protein (HMGB1), a member of the high mobility group protein superfamily, is an abundant and ubiquitously expressed nuclear protein. Intracellular HMGB1 is released by immune and necrotic cells and secreted HMGB1 activates a range of immune cells, contributing to the excessive release of inflammatory cytokines and promoting processes such as cell migration and adhesion. Moreover, HMGB1 is a typical damage-associated molecular pattern molecule that participates in various inflammatory and immune responses. In these ways, it plays a critical role in the pathophysiology of inflammatory diseases. Herein, we review the effects of HMGB1 on various immune cell types and describe the molecular mechanisms by which it contributes to the development of inflammatory disorders. Finally, we address the therapeutic potential of targeting HMGB1.</jats:p>","is_dataset_classified":null,"base_score":4.343805421853684,"endowment":4.343805421853684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33925132","pmcid":"PMC8145631","openalex_id":"https://openalex.org/W3158711521","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81730057, 81974293, 81873946, 82072201","title":null},{"funder_name":"Natural Science Foundation of Zhejiang Province","grant_id":"LY20H150011","title":null},{"funder_name":"the Military Medical Innovation Program of Chinese PLA","grant_id":"18CXZ026","title":null},{"funder_name":"the Zhejiang Province Medicine and Health Science and Technology Program","grant_id":"2021427564","title":null}],"total_grants":4,"fwci":5.8539,"citation_percentile":0.97762685,"influential_citations":0,"citation_trend":[{"year":2021,"count":5},{"year":2022,"count":10},{"year":2023,"count":16},{"year":2024,"count":14},{"year":2025,"count":24},{"year":2026,"count":7}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2073-4409/10/5/1044/pdf","host_type":"journal"},{"url":"https://www.mdpi.com/2073-4409/10/5/1044/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/cells10051044","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33925132","host_type":"repository"},{"url":"https://doaj.org/article/d5a0c75fc44d45e0965eec6be9831aa7","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/cells10051044","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8145631","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8145631","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8145631?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Advanced Glycation End Products research","Immune Response and Inflammation","Natural Antidiabetic Agents Studies","Animals","Cytokines","HMGB1 Protein","Humans","Immunity","Immunity, Cellular","Inflammation"],"mesh_terms":["Animals","Humans","Immunity","Immunity, Cellular","Inflammation","Cytokines","HMGB1 Protein"],"keywords":["HMGB1","Immune system","High-mobility group","Inflammation","Cell biology","Biology","Immunology","Biochemistry","Gene","Immune cells","Damage-associated Molecular Pattern","High Mobility Group Box-1 Protein","Inflammatory Disorders"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T04:45:01.338213Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}