{"doi":"10.3390/cells10040820","title":"TRIM32 and Malin in Neurological and Neuromuscular Rare Diseases","abstract":"Tripartite motif (TRIM) proteins are RING E3 ubiquitin ligases defined by a shared domain structure. Several of them are implicated in rare genetic diseases, and mutations in TRIM32 and TRIM-like malin are associated with Limb-Girdle Muscular Dystrophy R8 and Lafora disease, respectively. These two proteins are evolutionary related, share a common ancestor, and both display NHL repeats at their C-terminus. Here, we revmniew the function of these two related E3 ubiquitin ligases discussing their intrinsic and possible common pathophysiological pathways.","journal":"Cells","year":2021,"id":181093,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":731322,"name":"Xiong Lu","orcid":"0000-0001-6367-430X","position":1,"is_corresponding":false},{"id":251533,"name":"Maria Adelaida García-Gimeno","orcid":"0000-0002-6483-3912","position":2,"is_corresponding":false},{"id":295409,"name":"Elisa Lazzari","orcid":"0000-0001-5299-7525","position":3,"is_corresponding":false},{"id":251532,"name":"Pascual Sanz","orcid":"0000-0002-2399-4103","position":4,"is_corresponding":false},{"id":337331,"name":"Germana Meroni","orcid":"0000-0003-2531-114X","position":5,"is_corresponding":false},{"id":731321,"name":"Lorena Kumarasinghe","orcid":"0000-0002-8993-3565","position":0,"is_corresponding":true}],"reference_count":100,"raw_metadata":null,"created_at":"2026-07-18T23:48:01.257885Z","pmid":"33917450","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}