{"doi":"10.3390/cancers16234027","title":"Changes in Skin Cancer-Related Behaviors, Distress, and Beliefs in Response to Receipt of Low- to Moderate-Penetrance Genetic Test Results for Skin Cancer Risk","abstract":"Background. Little is known about the impact of low- to moderate-penetrance genetic testing for skin cancer, which is a promising approach to skin cancer prevention. Methods. To address this deficit, we conducted an analysis comparing changes in skin cancer-related behaviors, distress, and beliefs measured at a baseline and twice after the receipt of skin cancer precision prevention materials containing MC1R risk feedback (higher or average risk) among 568 non-Hispanic White (NHW) and 463 Hispanic participants. Results. Regression analyses identified decreased average weekend hours in the sun (β = −0.25; 95% CI, −0.46–[−0.04]) and increased average skin cancer worry (β = 0.09; 95% CI, 0.01–0.18) among higher-risk NHW participants at the first but not second follow-up. On average, higher-risk NHW and Hispanic participants reported a persistent increased risk of developing skin cancer compared with similar others (β = 0.49; 95% CI, 0.33, 0.65; β = 0.42; 95% CI, 0.17, 0.67, respectively). Conclusions.MC1R genetic testing resulted in durable elevated skin cancer risk perceptions and shorter-term behavior changes among higher-risk individuals. Although higher-risk participants reported slight heightened worry at the first follow-up, the overall levels of skin cancer-related distress were low. The lack of sustained behavioral changes highlights the need for intervention reinforcement in precision prevention approaches to reduce cancer risk.","journal":"Cancers","year":2024,"id":506895,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9405,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":799045,"name":"John Charles A. Lacson","orcid":"0000-0002-3444-7666","position":1,"is_corresponding":false},{"id":399199,"name":"Steven K. Sutton","orcid":"0000-0002-2504-7601","position":2,"is_corresponding":false},{"id":370723,"name":"Youngchul Kim","orcid":"0000-0002-2307-0330","position":3,"is_corresponding":false},{"id":390462,"name":"Susan T. Vadaparampil","orcid":"0000-0002-1052-6917","position":4,"is_corresponding":false},{"id":1358321,"name":"Brenda Soto-Torres","orcid":"0000-0003-1631-3522","position":5,"is_corresponding":false},{"id":500612,"name":"Jennifer L. Hay","orcid":"0000-0002-3492-9331","position":6,"is_corresponding":false},{"id":264813,"name":"Peter A. Kanetsky","orcid":"0000-0002-5567-9618","position":7,"is_corresponding":false},{"id":1358632,"name":"Monica Khadka","orcid":null,"position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T02:10:58.484528Z","pmid":"39682213","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}