{"doi":"10.3390/cancers15194689","title":"Estrogen Receptor Signaling in Breast Cancer","abstract":"<jats:p>Estrogen receptor (ER) signaling is a critical regulator of cell proliferation, differentiation, and survival in breast cancer (BC) and other hormone-sensitive cancers. In this review, we explore the mechanism of ER-dependent downstream signaling in BC and the role of estrogens as growth factors necessary for cancer invasion and dissemination. The significance of the clinical implications of ER signaling in BC, including the potential of endocrine therapies that target estrogens’ synthesis and ER-dependent signal transmission, such as aromatase inhibitors or selective estrogen receptor modulators, is discussed. As a consequence, the challenges associated with the resistance to these therapies resulting from acquired ER mutations and potential strategies to overcome them are the critical point for the new treatment strategies’ development.</jats:p>","journal":"Cancers","year":2023,"id":677245,"datarank":0.7886243058041673,"base_score":5.2574953720277815,"endowment":5.2574953720277815,"self_citation_contribution":0.7886243058041673,"citation_network_contribution":0.0,"self_endowment_contribution":0.7886243058041673,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":191,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":488609,"name":"Marzena Baran","orcid":"0000-0002-6985-435X","position":1,"is_corresponding":false},{"id":1769522,"name":"Ewa Błaszczak","orcid":"0000-0001-8434-1045","position":2,"is_corresponding":false},{"id":1769523,"name":"Alicja Przybyszewska-Podstawka","orcid":null,"position":3,"is_corresponding":false},{"id":1769524,"name":"Joanna Kałafut","orcid":"0000-0002-7452-8874","position":4,"is_corresponding":false},{"id":1513957,"name":"Jolanta Smok-Kalwat","orcid":null,"position":5,"is_corresponding":false},{"id":1769525,"name":"Magdalena Dmoszyńska-Graniczka","orcid":"0000-0002-6248-0930","position":6,"is_corresponding":false},{"id":1769526,"name":"Michał Kiełbus","orcid":"0000-0001-6156-6217","position":7,"is_corresponding":false},{"id":1769527,"name":"Andrzej Stepulak","orcid":"0000-0002-1872-394X","position":8,"is_corresponding":false},{"id":1769520,"name":"Paulina Miziak","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Estrogen Receptor Signaling in Breast Cancer","abstract":"<jats:p>Estrogen receptor (ER) signaling is a critical regulator of cell proliferation, differentiation, and survival in breast cancer (BC) and other hormone-sensitive cancers. In this review, we explore the mechanism of ER-dependent downstream signaling in BC and the role of estrogens as growth factors necessary for cancer invasion and dissemination. The significance of the clinical implications of ER signaling in BC, including the potential of endocrine therapies that target estrogens’ synthesis and ER-dependent signal transmission, such as aromatase inhibitors or selective estrogen receptor modulators, is discussed. As a consequence, the challenges associated with the resistance to these therapies resulting from acquired ER mutations and potential strategies to overcome them are the critical point for the new treatment strategies’ development.</jats:p>","is_dataset_classified":null,"base_score":5.2574953720277815,"endowment":5.2574953720277815,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37835383","pmcid":"PMC10572081","openalex_id":"https://openalex.org/W4386996041","authors":[],"funders":[{"funder_name":"Medical University of Lublin","grant_id":"DS715","title":null}],"total_grants":1,"fwci":40.7661,"citation_percentile":0.99882221,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":44},{"year":2025,"count":80},{"year":2026,"count":66}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2072-6694/15/19/4689/pdf?version=1695442710","host_type":"journal"},{"url":"https://www.mdpi.com/2072-6694/15/19/4689/pdf?version=1695442710","host_type":"publisher"},{"url":"https://www.mdpi.com/2072-6694/15/19/4689/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/cancers15194689","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37835383","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10572081","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10572081/pdf/cancers-15-04689.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10572081","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10572081?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Estrogen and related hormone effects","HER2/EGFR in Cancer Research","Advanced Breast Cancer Therapies"],"mesh_terms":[],"keywords":["Estrogen receptor","Aromatase","Breast cancer","Cancer research","Estrogen","Signal transduction","Regulator","Cancer","Receptor","Estrogen receptor alpha","Mechanism (biology)","Selective estrogen receptor modulator","Biology","Endocrine system","Estrogen receptor beta","Medicine","Internal medicine","Hormone","Cell biology","Genetics","Gene","Post-translational modifications","ER","Therapeutic Targeting","Er Signaling","Er Coregulators"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"uniprot"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T03:52:26.233932Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}