{"doi":"10.3390/cancers15184546","title":"Associations between the Gut Microbiota, Race, and Ethnicity of Patients with Colorectal Cancer: A Pilot and Feasibility Study","abstract":"BACKGROUND: Colorectal cancer (CRC) is more prevalent among some racial and ethnic minority and low socioeconomic status populations. Although the gut microbiota is a risk factor for CRC and varies with race and ethnicity, its role in CRC disparities remains poorly understood. METHODS: We examined the feasibility of recruiting sociodemographically diverse CRC patients for a microbiome study involving a home stool collection. We also explored whether race and ethnicity were associated with gut microbiome composition. We recruited Black/African American, Hispanic/Latino, and non-Hispanic White patients who were receiving care for active CRC to complete a comprehensive dietary and lifestyle survey, self-collect a stool sample, and complete an exit interview. Gut microbial diversity and composition were analyzed using 16S rRNA gene sequencing. RESULTS: 30 individuals consented (of 35 who were eligible and contacted) with 5 (17%) Black/African American, 11 (37%) Hispanic/Latino, and 14 (46%) non-Hispanic White. A total of 22 (73%) completed the dietary and lifestyle survey; 18 (63%) returned a stool sample. Even after controlling for socioeconomic, dietary, or treatment-related covariates, microbiome composition was associated with race and ethnicity. Fusobacteriota (a phylum associated with the development and progression of CRC) was significantly higher in the Black/African American group compared to others, and microbial diversity was higher in samples from non-Hispanic White individuals compared to Hispanic/Latino individuals. CONCLUSION: Our study shows that it is feasible to recruit and collect stool samples from diverse individuals with CRC and found significant associations in gut microbial structure with race and ethnicity.","journal":"Cancers","year":2023,"id":337613,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9579,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":235404,"name":"Than S. Kyaw","orcid":"0000-0002-7933-8615","position":1,"is_corresponding":false},{"id":827097,"name":"Kai Trepka","orcid":"0000-0002-8672-6317","position":2,"is_corresponding":false},{"id":44595,"name":"Anita L. Stewart","orcid":"0000-0002-4967-9013","position":3,"is_corresponding":false},{"id":1069439,"name":"Rosa Mora","orcid":"0000-0002-8370-8666","position":4,"is_corresponding":false},{"id":1070041,"name":"Dalila Stanfield","orcid":null,"position":5,"is_corresponding":false},{"id":1070042,"name":"Kendall Levine","orcid":null,"position":6,"is_corresponding":false},{"id":332144,"name":"Erin L. Van Blarigan","orcid":"0000-0001-5079-3385","position":7,"is_corresponding":false},{"id":36111,"name":"Alan P. Venook","orcid":"0000-0001-9749-6548","position":8,"is_corresponding":false},{"id":36356,"name":"Peter J. Turnbaugh","orcid":"0000-0002-0888-2875","position":9,"is_corresponding":false},{"id":107673,"name":"Tung T. Nguyen","orcid":"0000-0001-9897-6551","position":10,"is_corresponding":false},{"id":482607,"name":"Chloé E. Atreya","orcid":"0000-0003-2954-1727","position":11,"is_corresponding":false},{"id":107676,"name":"Sorbarikor Piawah","orcid":"0000-0002-1655-6113","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T01:10:31.133446Z","pmid":"37760515","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}