{"doi":"10.3390/cancers14081901","title":"Outcomes and Toxicities of Modern Combined Modality Therapy with Atezolizumab Plus Bevacizumab and Radiation Therapy for Hepatocellular Carcinoma","abstract":"Atezolizumab plus bevacizumab has become frontline therapy for unresectable HCC. The compatibility of atezolizumab/bevacizumab with liver-directed RT has not been reported. Methods: HCC patients treated with liver-directed RT and atezolizumab/bevacizumab between 1/2020−11/2021 were included. Toxicity and outcomes were retrospectively recorded. For ALCs, we matched the analysis to a previously cohort of RT-treated HCC patients who did not receive atezolizumab/bevacizumab. Survival and time-to-liver-failure were analyzed using Kaplan−Meier. Results: Of 21 patients, with a median follow-up of 9.5 months, the median OS was 16.1 months. Post-RT, all patients had reduced tumors or treatment response. There were no ≥Grade 3 RT-related toxicities. Autoimmune complications occurred in two patients (9.5%), and GI bleeding in three patients (14.3%). Liver function remained stable post-RT. There was a marked decrease in ALCs immediately post-RT (post-RT/pre-RT ratio 47.3%, p < 0.0001), restored by 1 month to pre-treatment baseline (1-month post-RT/pre-RT ratio 95.1%, n.s.). Compared to HCC patients treated with RT alone, post-RT ALC recovery was faster with atezolizumab/bevacizumab (p = 0.009). Conclusion: In this first reported experience of RT with modern systemic therapy for HCC, combination therapy is safe and well-tolerated. As a favorable prognosticator, there appears to be faster recovery of ALC among patients who received RT with atezolizumab/bevacizumab.","journal":"Cancers","year":2022,"id":247187,"datarank":0.5375278407684165,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.0,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9381,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":512279,"name":"Brian De","orcid":"0000-0003-3468-3359","position":1,"is_corresponding":false},{"id":724608,"name":"Chike O. Abana","orcid":"0000-0003-0209-8470","position":2,"is_corresponding":false},{"id":573504,"name":"Sunyoung S. Lee","orcid":"0000-0002-5954-5991","position":3,"is_corresponding":false},{"id":226645,"name":"Milind Javle","orcid":"0000-0001-9158-0941","position":4,"is_corresponding":false},{"id":54196,"name":"Ahmed O. Kaseb","orcid":"0000-0002-9491-0587","position":5,"is_corresponding":false},{"id":332170,"name":"Jean‐Nicolas Vauthey","orcid":"0000-0003-4921-5427","position":6,"is_corresponding":false},{"id":842910,"name":"Hop Sanderson Tran Cao","orcid":null,"position":7,"is_corresponding":false},{"id":254922,"name":"Albert C. Koong","orcid":"0000-0001-9824-1643","position":8,"is_corresponding":false},{"id":380273,"name":"Grace L. Smith","orcid":"0000-0002-3171-2911","position":9,"is_corresponding":false},{"id":60605,"name":"Cullen M. Taniguchi","orcid":"0000-0002-8052-3316","position":10,"is_corresponding":false},{"id":428202,"name":"Emma B. Holliday","orcid":"0000-0002-4362-461X","position":11,"is_corresponding":false},{"id":341838,"name":"Prajnan Das","orcid":"0000-0002-3845-0707","position":12,"is_corresponding":false},{"id":227744,"name":"Eugene J. Koay","orcid":"0000-0001-7675-3461","position":13,"is_corresponding":false},{"id":355311,"name":"Ethan B. Ludmir","orcid":"0000-0002-5472-5344","position":14,"is_corresponding":false},{"id":884606,"name":"Gohar Manzar","orcid":"0000-0003-0331-7102","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:23:53.369530Z","pmid":"35454808","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}