{"doi":"10.3390/cancers14041072","title":"The Impact of Frailty Screening on Radiation Treatment Modification","abstract":"<jats:p>Background: Care overburden makes it difficult to perform comprehensive geriatric assessments (CGAs) in oncology settings. We analyzed if screening tools modified radiotherapy in oncogeriatric patients. Methods: Patients ≥ 65 years, irradiated between December 2020 and March 2021 at the Hospital Provincial de Castellón, completed the frailty G8 and estimated survival Charlson questionnaires. The cohort was stratified between G8 score ≤ 14 (fragile) or &gt;14 (robust); the cutoff point for the Charlson index was established at five. Results: Of 161 patients; 69.4% were male, the median age was 75 years (range 65–91), and the prevailing performance status (PS) was 0–1 (83.1%). Overall, 28.7% of the cohort were frail based on G8 scores, while the estimated survival at 10 years was 2.25% based on the Charlson test. The treatment administered changed up to 21% after frailty analysis. The therapies prescribed were 5.8 times more likely to be modified in frail patients based on the G8 test. In addition, patients ≥ 85 years (p = 0.01), a PS ≥ 2 (p = 0.008), and limited mobility (p = 0.024) were also associated with a potential change. Conclusions: CGAs remain the optimal assessment tool in oncogeriatry. However, we found that the G8 fragility screening test, which is easier to integrate into patient consultations, is a reliable and efficient aid to rapid decision making.</jats:p>","journal":"Cancers","year":2022,"id":643998,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1675941,"name":"Carlos Ferrer-Ramos","orcid":null,"position":1,"is_corresponding":false},{"id":1675942,"name":"Virginia Morilllo-Macías","orcid":"0000-0003-3102-9001","position":2,"is_corresponding":false},{"id":1675943,"name":"Marta Rodríguez-Cordón","orcid":null,"position":3,"is_corresponding":false},{"id":1675944,"name":"Ángel Sánchez-Iglesias","orcid":"0000-0003-2872-8821","position":4,"is_corresponding":false},{"id":1675945,"name":"Inmaculada Beato-Tortajada","orcid":null,"position":5,"is_corresponding":false},{"id":1675946,"name":"Alicia Francés-Muñoz","orcid":null,"position":6,"is_corresponding":false},{"id":1675947,"name":"Rodrigo Muelas-Soria","orcid":null,"position":7,"is_corresponding":false},{"id":1675948,"name":"Teresa Piquer-Camañes","orcid":null,"position":8,"is_corresponding":false},{"id":1675949,"name":"Ana Isabel Santafé-Jiménez","orcid":"0000-0002-1302-9086","position":9,"is_corresponding":false},{"id":1675950,"name":"Vanessa Aznar-Tortonda","orcid":"0000-0003-4205-8676","position":10,"is_corresponding":false},{"id":1675951,"name":"Carlos Ferrer-Albiach","orcid":"0000-0001-9122-7646","position":11,"is_corresponding":false},{"id":1675940,"name":"Encarnación Fernández-Camacho","orcid":"0000-0002-3502-9693","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Impact of Frailty Screening on Radiation Treatment Modification","abstract":"<jats:p>Background: Care overburden makes it difficult to perform comprehensive geriatric assessments (CGAs) in oncology settings. We analyzed if screening tools modified radiotherapy in oncogeriatric patients. Methods: Patients ≥ 65 years, irradiated between December 2020 and March 2021 at the Hospital Provincial de Castellón, completed the frailty G8 and estimated survival Charlson questionnaires. The cohort was stratified between G8 score ≤ 14 (fragile) or &gt;14 (robust); the cutoff point for the Charlson index was established at five. Results: Of 161 patients; 69.4% were male, the median age was 75 years (range 65–91), and the prevailing performance status (PS) was 0–1 (83.1%). Overall, 28.7% of the cohort were frail based on G8 scores, while the estimated survival at 10 years was 2.25% based on the Charlson test. The treatment administered changed up to 21% after frailty analysis. The therapies prescribed were 5.8 times more likely to be modified in frail patients based on the G8 test. In addition, patients ≥ 85 years (p = 0.01), a PS ≥ 2 (p = 0.008), and limited mobility (p = 0.024) were also associated with a potential change. Conclusions: CGAs remain the optimal assessment tool in oncogeriatry. However, we found that the G8 fragility screening test, which is easier to integrate into patient consultations, is a reliable and efficient aid to rapid decision making.</jats:p>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35205820","pmcid":"PMC8870720","openalex_id":"https://openalex.org/W4213195994","authors":[],"funders":[],"total_grants":0,"fwci":0.748,"citation_percentile":0.65066394,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2072-6694/14/4/1072/pdf?version=1645406974","host_type":"journal"},{"url":"https://www.mdpi.com/2072-6694/14/4/1072/pdf?version=1645406974","host_type":"publisher"},{"url":"https://www.mdpi.com/2072-6694/14/4/1072/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/cancers14041072","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35205820","host_type":"repository"},{"url":"https://doaj.org/article/695e7f575e8745e790577e1d9861f762","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/cancers14041072","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8870720","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8870720","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8870720?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Frailty in Older Adults","Nutrition and Health in Aging","Cancer survivorship and care"],"mesh_terms":[],"keywords":["Medicine","Intensive care medicine","Frailty","G8","Charlson","Oncogeriatry","Therapy Modification"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Peace, Justice and strong institutions"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-08T20:27:37.319417Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}