{"doi":"10.3390/cancers14030693","title":"Biopsy and Margins Optimize Outcomes after Thermal Ablation of Colorectal Liver Metastases","abstract":"Background: Thermal ablation is a definitive local treatment for selected colorectal liver metastases (CLM) that can be ablated with adequate margins. A critical limitation has been local tumor progression (LTP). Methods: This prospective, single-group, phase 2 study enrolled patients with CLM < 5 cm in maximum diameter, at a tertiary cancer center between November 2009 and February 2019. Biopsy of the ablation zone center and margin was performed immediately after ablation. Viable tumor in tissue biopsy and ablation margins < 5 mm were assessed as predictors of 12-month LTP. Results: We enrolled 107 patients with 182 CLMs. Mean tumor size was 2.0 (range, 0.6–4.6) cm. Microwave ablation was used in 51% and radiofrequency ablation in 49% of tumors. The 12- and 24-month cumulative incidence of LTP was 22% (95% confidence interval [CI]: 17, 29) and 29% (95% CI: 23, 36), respectively. LTP at 12 months was 7% (95% CI: 3, 14) for the biopsy tumor-negative ablation zone with margins ≥ 5 mm vs. 63% (95% CI: 35, 85) for the biopsy-positive ablation zone with margins < 5 mm (p < 0.001). Conclusions: Biopsy-proven complete tumor ablation with margins of at least 5 mm achieves optimal local tumor control for CLM, regardless of the ablation modality used.","journal":"Cancers","year":2022,"id":247977,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.966,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":90720,"name":"Efsevia Vakiani","orcid":"0000-0003-0227-3523","position":1,"is_corresponding":false},{"id":266133,"name":"Mithat Gönen","orcid":"0000-0001-8683-8477","position":2,"is_corresponding":false},{"id":301651,"name":"Nancy E. Kemeny","orcid":"0000-0002-0929-9542","position":3,"is_corresponding":false},{"id":277369,"name":"Carlie Sigel","orcid":"0000-0001-6276-3968","position":4,"is_corresponding":false},{"id":90755,"name":"Leonard B. Saltz","orcid":"0000-0001-8353-4670","position":5,"is_corresponding":false},{"id":301650,"name":"Karen T. Brown","orcid":"0000-0003-2434-0037","position":6,"is_corresponding":false},{"id":301648,"name":"Anne M. Covey","orcid":"0000-0002-1477-8468","position":7,"is_corresponding":false},{"id":245673,"name":"Joseph P. Erinjeri","orcid":"0000-0003-1876-727X","position":8,"is_corresponding":false},{"id":301649,"name":"Lynn A. Brody","orcid":"0000-0002-9786-3085","position":9,"is_corresponding":false},{"id":301653,"name":"Etay Ziv","orcid":"0000-0002-3188-0085","position":10,"is_corresponding":false},{"id":301652,"name":"Hooman Yarmohammadi","orcid":"0000-0002-3127-9222","position":11,"is_corresponding":false},{"id":579677,"name":"Henry Kunin","orcid":"0000-0002-4056-0219","position":12,"is_corresponding":false},{"id":291553,"name":"Afşar Barlas","orcid":"0000-0002-4077-0777","position":13,"is_corresponding":false},{"id":303266,"name":"Elena N. Petre","orcid":null,"position":14,"is_corresponding":false},{"id":301654,"name":"T. Peter Kingham","orcid":"0000-0002-3359-3186","position":15,"is_corresponding":false},{"id":303268,"name":"Michael I. D’Angelica","orcid":null,"position":16,"is_corresponding":false},{"id":50788,"name":"Katia Manova","orcid":"0000-0003-0915-6696","position":17,"is_corresponding":false},{"id":403829,"name":"Stephen B. Solomon","orcid":"0000-0001-5108-1021","position":18,"is_corresponding":false},{"id":301657,"name":"Constantinos T. Sofocleous","orcid":"0000-0002-3142-1399","position":19,"is_corresponding":false},{"id":581588,"name":"Nikiforos Vasiniotis Kamarinos","orcid":"0000-0002-1162-1270","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T00:24:09.893688Z","pmid":"35158963","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}