{"doi":"10.3390/cancers13164186","title":"DUOX2, a New Biomarker for Disseminated Gastric Cancer’s Response to Low Dose Radiation in Mice","abstract":"Treatment options are rather limited for gastrointestinal cancer patients whose disease has disseminated into the intra-abdominal cavity. Here, we designed pre-clinical studies to evaluate the potential application of chemopotentiation by Low Dose Fractionated Radiation Therapy (LDFRT) for disseminated gastric cancer and evaluate the role of a likely biomarker, Dual Oxidase 2 (DUOX2). Nude mice were injected orthotopically with human gastric cancer cells expressing endogenous or reduced levels of DUOX2 and randomly assigned to four treatment groups: 1; vehicle alone, 2; modified regimen of docetaxel, cisplatin and 5'-fluorouracil (mDCF) for three consecutive days, 3; Low Dose- Whole Abdomen Radiation Therapy (LD-WART) (5 fractions of 0.15 Gy in three days), 4; mDCF and LD-WART. The combined regimen increased the odds of preventing cancer dissemination (mDCF + LD-WART OR = 4.16; 80% CI = 1.0, 17.29) in the DUOX2 positive tumors, while tumors expressing lower DUOX2 levels were more responsive to mDCF alone with no added benefit from LD-WART. The molecular mechanisms underlying DUOX2 effects in response to the combined regimen include NF-κB upregulation. These data are particularly important since our study indicates that about 33% of human stomach adenocarcinoma do not express DUOX2. DUOX2 thus seems a likely biomarker for potential clinical application of chemopotentiation by LD-WART.","journal":"Cancers","year":2021,"id":209962,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9652,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":380064,"name":"Eduardo Solano-Gonzàlez","orcid":null,"position":1,"is_corresponding":false},{"id":699466,"name":"Mariana Bonjiorno Martins","orcid":"0000-0002-9659-6528","position":2,"is_corresponding":false},{"id":474928,"name":"Xinrong Ma","orcid":"0000-0003-2733-9859","position":3,"is_corresponding":false},{"id":476019,"name":"Kayla M. Tighe","orcid":null,"position":4,"is_corresponding":false},{"id":798548,"name":"Andrea Casildo","orcid":null,"position":5,"is_corresponding":false},{"id":798549,"name":"Andrew Zodda","orcid":null,"position":6,"is_corresponding":false},{"id":798037,"name":"Christopher Johnstone","orcid":"0000-0002-5830-4264","position":7,"is_corresponding":false},{"id":798038,"name":"Yannick Poirier","orcid":"0000-0002-6548-8321","position":8,"is_corresponding":false},{"id":798039,"name":"Javed Mahmood","orcid":"0000-0002-0123-535X","position":9,"is_corresponding":false},{"id":407499,"name":"Kavita Bhalla","orcid":"0000-0001-9271-2838","position":10,"is_corresponding":false},{"id":798550,"name":"Sheri Li","orcid":null,"position":11,"is_corresponding":false},{"id":407501,"name":"Rena G. Lapidus","orcid":"0000-0002-4422-743X","position":12,"is_corresponding":false},{"id":379329,"name":"France Carrier","orcid":"0000-0002-5517-5284","position":13,"is_corresponding":false},{"id":798547,"name":"Palak R. Parekh","orcid":null,"position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:52:08.869117Z","pmid":"34439340","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}