{"doi":"10.3390/cancers13133245","title":"The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study","abstract":"<jats:p>We evaluated the association between short-term change in body mass index (BMI) and breast density during a 1 year weight-loss intervention (Manchester, UK). We included 65 premenopausal women (35–45 years, ≥7 kg adult weight gain, family history of breast cancer). BMI and breast density (semi-automated area-based, automated volume-based) were measured at baseline, 1 year, and 2 years after study entry (1 year post intervention). Cross-sectional (between-women) and short-term change (within-women) associations between BMI and breast density were measured using repeated-measures correlation coefficients and multivariable linear mixed models. BMI was positively correlated with dense volume between-women (r = 0.41, 95%CI: 0.17, 0.61), but less so within-women (r = 0.08, 95%CI: −0.16, 0.28). There was little association with dense area (between-women r = −0.12, 95%CI: −0.38, 0.16; within-women r = 0.01, 95%CI: −0.24, 0.25). BMI and breast fat were positively correlated (volume: between r = 0.77, 95%CI: 0.69, 0.84, within r = 0.58, 95%CI: 0.36, 0.75; area: between r = 0.74, 95%CI: 0.63, 0.82, within r = 0.45, 95%CI: 0.23, 0.63). Multivariable models reported similar associations. Exploratory analysis suggested associations between BMI gain from 20 years and density measures (standard deviation change per +5 kg/m2 BMI: dense area: +0.61 (95%CI: 0.12, 1.09); fat volume: −0.31 (95%CI: −0.62, 0.00)). Short-term BMI change is likely to be positively associated with breast fat, but we found little association with dense tissue, although power was limited by small sample size.</jats:p>","journal":"Cancers","year":2021,"id":625831,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1085601,"name":"Adam R. Brentnall","orcid":"0000-0001-6327-4357","position":1,"is_corresponding":false},{"id":890669,"name":"Susan Astley","orcid":"0000-0002-2989-2765","position":2,"is_corresponding":false},{"id":420948,"name":"Jack Cuzick","orcid":"0000-0001-7420-7512","position":3,"is_corresponding":false},{"id":52732,"name":"D. Gareth Evans","orcid":"0000-0002-8482-5784","position":4,"is_corresponding":false},{"id":1618692,"name":"Ruth M. L. Warren","orcid":null,"position":5,"is_corresponding":false},{"id":187894,"name":"Anthony Howell","orcid":null,"position":6,"is_corresponding":false},{"id":586157,"name":"Michelle Harvie","orcid":"0000-0001-9761-3089","position":7,"is_corresponding":false},{"id":1618691,"name":"Emma C. Atakpa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study","abstract":"<jats:p>We evaluated the association between short-term change in body mass index (BMI) and breast density during a 1 year weight-loss intervention (Manchester, UK). We included 65 premenopausal women (35–45 years, ≥7 kg adult weight gain, family history of breast cancer). BMI and breast density (semi-automated area-based, automated volume-based) were measured at baseline, 1 year, and 2 years after study entry (1 year post intervention). Cross-sectional (between-women) and short-term change (within-women) associations between BMI and breast density were measured using repeated-measures correlation coefficients and multivariable linear mixed models. BMI was positively correlated with dense volume between-women (r = 0.41, 95%CI: 0.17, 0.61), but less so within-women (r = 0.08, 95%CI: −0.16, 0.28). There was little association with dense area (between-women r = −0.12, 95%CI: −0.38, 0.16; within-women r = 0.01, 95%CI: −0.24, 0.25). BMI and breast fat were positively correlated (volume: between r = 0.77, 95%CI: 0.69, 0.84, within r = 0.58, 95%CI: 0.36, 0.75; area: between r = 0.74, 95%CI: 0.63, 0.82, within r = 0.45, 95%CI: 0.23, 0.63). Multivariable models reported similar associations. Exploratory analysis suggested associations between BMI gain from 20 years and density measures (standard deviation change per +5 kg/m2 BMI: dense area: +0.61 (95%CI: 0.12, 1.09); fat volume: −0.31 (95%CI: −0.62, 0.00)). Short-term BMI change is likely to be positively associated with breast fat, but we found little association with dense tissue, although power was limited by small sample size.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34209579","pmcid":"PMC8269424","openalex_id":null,"authors":[],"funders":[{"funder_name":"Cancer Research UK","grant_id":"C569/A16891","title":null},{"funder_name":"NIHR Manchester Biomedical Research Centre","grant_id":"IS-BRC-1215-20007","title":null},{"funder_name":"Barts Charity","grant_id":"MGU0461","title":null}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2072-6694/13/13/3245/pdf?version=1625563418","host_type":"publisher"},{"url":"https://www.mdpi.com/2072-6694/13/13/3245/pdf","host_type":"publisher"},{"url":"https://research.manchester.ac.uk/en/publications/dceeaeb8-e157-4018-8575-715b590446ba","host_type":"repository"},{"url":"https://doaj.org/article/c19a04eaa9f14be49632d92075665877","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/cancers13133245","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8269424","host_type":"repository"},{"url":"https://qmro.qmul.ac.uk/xmlui/handle/123456789/74688","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8269424","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8269424?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":[],"keywords":["Weight loss","body mass index","Breast Cancer Risk","Mammographic Density","Premenopausal","Breast Cancer Prevention"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T11:05:44.693723Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}