{"doi":"10.3390/cancers12123495","title":"Contrast-Enhanced Mammography for Screening Women after Breast Conserving Surgery","abstract":"To investigate the value of contrast-enhanced mammography (CEM) compared to full-field digital mammography (FFDM) in screening breast cancer patients after breast-conserving surgery (BCS), this Health Insurance Portability and Accountability Act-compliant, institutional review board-approved retrospective, single-institution study included 971 CEM exams in 541 asymptomatic patients treated with BCS who underwent screening CEM between January 2013 and November 2018. Histopathology, or at least a one-year follow-up, was used as the standard of reference. Twenty-one of 541 patients (3.9%) were diagnosed with ipsi- or contralateral breast cancer: six (28.6%) cancers were seen with low-energy images (equivalent to FFDM), an additional nine (42.9%) cancers were detected only on iodine (contrast-enhanced) images, and six interval cancers were identified within 365 days of a negative screening CEM. Of the 10 ipsilateral cancers detected on CEM, four were detected on low-energy images (40%). Of the five contralateral cancers detected on CEM, two were detected on low-energy images (40%). Overall, the cancer detection rate (CDR) for CEM was 15.4/1000 (15/971), and the positive predictive value (PPV3) of the biopsies performed was 42.9% (15/35). For findings seen on low-energy images, with or without contrast, the CDR was 6.2/1000 (6/971), and the PPV3 of the biopsies performed was 37.5% (6/16). In the post-BCS screening setting, CEM has a higher CDR than FFDM.","journal":"Cancers","year":2020,"id":92637,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9369,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":256910,"name":"Carolina Rossi Saccarelli","orcid":null,"position":1,"is_corresponding":false},{"id":351862,"name":"Daly Avendaño","orcid":"0000-0002-8433-7211","position":2,"is_corresponding":false},{"id":351860,"name":"Maria Adele Marino","orcid":"0000-0002-5614-2660","position":3,"is_corresponding":false},{"id":254403,"name":"Almir Galvão Vieira Bitencourt","orcid":"0000-0003-0192-9885","position":4,"is_corresponding":false},{"id":316456,"name":"Melissa Pilewskie","orcid":"0000-0003-0508-6424","position":5,"is_corresponding":false},{"id":353291,"name":"Varadan Sevilimedu","orcid":"0000-0002-0938-9396","position":6,"is_corresponding":false},{"id":351861,"name":"Janice S. Sung","orcid":"0000-0002-9067-9840","position":7,"is_corresponding":false},{"id":250549,"name":"Katja Pinker","orcid":"0000-0002-2722-7331","position":8,"is_corresponding":false},{"id":254406,"name":"Maxine S. Jochelson","orcid":"0000-0002-4012-2470","position":9,"is_corresponding":false},{"id":311743,"name":"Jill S. Gluskin","orcid":"0000-0002-6966-7597","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-18T22:30:31.563852Z","pmid":"33255412","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}