{"doi":"10.3390/cancers12061665","title":"Klotho and the Treatment of Human Malignancies","abstract":"Klotho was first discovered as an anti-ageing protein linked to a number of age-related disease processes, including cardiovascular, renal, musculoskeletal, and neurodegenerative conditions. Emerging research has also demonstrated a potential therapeutic role for Klotho in cancer biology, which is perhaps unsurprising given that cancer and ageing share similar molecular hallmarks. In addition to functioning as a tumour suppressor in numerous solid tumours and haematological malignancies, Klotho represents a candidate therapeutic target for patients with these diseases, the majority of whom have limited treatment options. Here, we examine contemporary evidence evaluating the anti-neoplastic effects of Klotho and describe the modulation of downstream oncogenic signalling pathways, including Wnt/β-catenin, FGF, IGF1, PIK3K/AKT, TGFβ, and the Unfolded Protein Response. We also discuss possible approaches to developing therapeutic Klotho and consider technological advances that may facilitate the delivery of Klotho through gene therapy.","journal":"Cancers","year":2020,"id":92890,"datarank":0.5606504427425053,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":0.0,"self_endowment_contribution":0.5606504427425053,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9462,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":464164,"name":"Jérôme Gouge","orcid":"0000-0003-4734-5412","position":1,"is_corresponding":false},{"id":464165,"name":"Christos Kontovounisios","orcid":"0000-0002-1828-1395","position":2,"is_corresponding":false},{"id":464166,"name":"Stella Nikolaou","orcid":"0000-0001-6450-6463","position":3,"is_corresponding":false},{"id":7895,"name":"Alan Ashworth","orcid":"0000-0003-1446-7878","position":4,"is_corresponding":false},{"id":364820,"name":"Kenneth Lim","orcid":"0000-0001-7178-2183","position":5,"is_corresponding":false},{"id":464167,"name":"Irene Chong","orcid":"0000-0003-1692-4411","position":6,"is_corresponding":false},{"id":464833,"name":"Aishani Sachdeva","orcid":null,"position":0,"is_corresponding":true}],"reference_count":169,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T22:30:31.563852Z","pmid":"32585905","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}