{"doi":"10.3390/brainsci12101360","title":"Cardiorespiratory Fitness as a Moderator of Sleep-Related Associations with Hippocampal Volume and Cognition","abstract":"= 30, age = 65.8 years, female = 73.3%). Wrist actigraphy provided objective measures of nighttime sleep including sleep duration, average wake bout length (WBL; sleep disturbance), and wake-to-sleep transition probability (WTSP; sleep consolidation). Cardiorespiratory fitness was quantified via cycle exercise using a modified heart rate recovery approach. Magnetic resonance imaging was used to determine hippocampal volume and the Mini-Mental State Examination was used to assess global cognition. Fitness moderated associations of sleep with hippocampal volume and cognitive performance, whereby the association of WBL-an index of poor sleep-with hippocampal atrophy was stronger among less-fit individuals, and the association of sleep duration with cognitive performance was stronger among more-fit individuals. Across the fitness levels, a longer WBL was associated with lower cognitive performance, and a higher WTSP-an index of more consolidated sleep-was associated with greater hippocampal volume. Sleep and fitness were unrelated to the volume of an amygdala control region, suggesting a degree of neuroanatomical specificity. In conclusion, higher cardiorespiratory fitness may attenuate sleep disturbance-related hippocampal atrophy and magnify the cognitive benefits of good sleep. Prospective studies are needed to confirm these findings.","journal":"Brain Sciences","year":2022,"id":295920,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8373,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":638789,"name":"Junyeon Won","orcid":"0000-0001-7900-9355","position":1,"is_corresponding":false},{"id":982123,"name":"Lauren R. Weiss","orcid":"0000-0003-0976-8502","position":2,"is_corresponding":false},{"id":487351,"name":"Casandra Nyhuis","orcid":"0000-0001-7189-808X","position":3,"is_corresponding":false},{"id":490122,"name":"Vadim Zipunnikov","orcid":"0000-0001-9864-2420","position":4,"is_corresponding":false},{"id":439252,"name":"Adam P. Spira","orcid":"0000-0003-1507-0995","position":5,"is_corresponding":false},{"id":385343,"name":"Teresa Liu‐Ambrose","orcid":"0000-0002-8297-5308","position":6,"is_corresponding":false},{"id":404785,"name":"Alexander J. Shackman","orcid":"0000-0002-3629-4704","position":7,"is_corresponding":false},{"id":638795,"name":"J. Carson Smith","orcid":"0000-0001-6142-0920","position":8,"is_corresponding":false},{"id":329633,"name":"Alfonso J. Alfini","orcid":"0000-0002-8743-8923","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":null,"created_at":"2026-07-19T00:31:12.531553Z","pmid":"36291294","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}