{"doi":"10.3390/brainsci11070909","title":"Comparison of Functional Connectivity in the Prefrontal Cortex during a Simple and an Emotional Go/No-Go Task in Female versus Male Groups: An fNIRS Study","abstract":"Inhibitory control is a cognitive process to suppress prepotent behavioral responses to stimuli. This study aimed to investigate prefrontal functional connectivity during a behavioral inhibition task and its correlation with the subject's performance. Additionally, we identified connections that are specific to the Go/No-Go task. The experiment was performed on 42 normal, healthy adults who underwent a vanilla baseline and a simple and emotional Go/No-Go task. Cerebral hemodynamic responses were measured in the prefrontal cortex using a 16-channel near infrared spectroscopy (NIRS) device. Functional connectivity was calculated from NIRS signals and correlated to the Go/No-Go performance. Strong connectivity was found in both the tasks in the right hemisphere, inter-hemispherically, and the left medial prefrontal cortex. Better performance (fewer errors, faster response) is associated with stronger prefrontal connectivity during the simple Go/No-Go in both sexes and the emotional Go/No-Go connectivity in males. However, females express a lower emotional Go/No-Go connectivity while performing better on the task. This study reports a complete prefrontal network during a simple and emotional Go/No-Go and its correlation with the subject's performance in females and males. The results can be applied to examine behavioral inhibitory control deficits in population with neurodevelopmental disorders.","journal":"Brain Sciences","year":2021,"id":192113,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9369,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":418816,"name":"Emma Condy","orcid":"0000-0003-2536-5930","position":1,"is_corresponding":false},{"id":704892,"name":"Soongho Park","orcid":"0000-0001-8771-8397","position":2,"is_corresponding":false},{"id":421977,"name":"Bruce H. Friedman","orcid":"0000-0003-0814-0393","position":3,"is_corresponding":false},{"id":418819,"name":"Amir Gandjbakhche","orcid":"0000-0003-2652-0162","position":4,"is_corresponding":false},{"id":436292,"name":"Thien Huu Nguyen","orcid":"0000-0003-3768-4736","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-18T23:49:39.281850Z","pmid":"34356143","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}