{"doi":"10.3390/brainsci10090579","title":"Obesity is Associated with Reduced Plasticity of the Human Motor Cortex","abstract":"<jats:p>Obesity is characterised by excessive body fat and is associated with several detrimental health conditions, including cardiovascular disease and diabetes. There is some evidence that people who are obese have structural and functional brain alterations and cognitive deficits. It may be that these neurophysiological and behavioural consequences are underpinned by altered plasticity. This study investigated the relationship between obesity and plasticity of the motor cortex in people who were considered obese (n = 14, nine males, aged 35.4 ± 14.3 years) or healthy weight (n = 16, seven males, aged 26.3 ± 8.5 years). A brain stimulation protocol known as continuous theta burst transcranial magnetic stimulation was applied to the motor cortex to induce a brief suppression of cortical excitability. The suppression of cortical excitability was quantified using single-pulse transcranial magnetic stimulation to record and measure the amplitude of the motor evoked potential in a peripheral hand muscle. Therefore, the magnitude of suppression of the motor evoked potential by continuous theta burst stimulation was used as a measure of the capacity for plasticity of the motor cortex. Our results demonstrate that the healthy-weight group had a significant suppression of cortical excitability following continuous theta burst stimulation (cTBS), but there was no change in excitability for the obese group. Comparing the response to cTBS between groups demonstrated that there was an impaired plasticity response for the obese group when compared to the healthy-weight group. This might suggest that the capacity for plasticity is reduced in people who are obese. Given the importance of plasticity for human behaviour, our results add further emphasis to the potentially detrimental health effects of obesity.</jats:p>","journal":"Brain Sciences","year":2020,"id":622630,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":839232,"name":"Michael C. Ridding","orcid":"0000-0001-5657-9136","position":1,"is_corresponding":false},{"id":715055,"name":"Brenton Hordacre","orcid":"0000-0002-7129-6684","position":2,"is_corresponding":false},{"id":1608806,"name":"Sophia X. Sui","orcid":"0000-0001-6388-1261","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Obesity is Associated with Reduced Plasticity of the Human Motor Cortex","abstract":"<jats:p>Obesity is characterised by excessive body fat and is associated with several detrimental health conditions, including cardiovascular disease and diabetes. There is some evidence that people who are obese have structural and functional brain alterations and cognitive deficits. It may be that these neurophysiological and behavioural consequences are underpinned by altered plasticity. This study investigated the relationship between obesity and plasticity of the motor cortex in people who were considered obese (n = 14, nine males, aged 35.4 ± 14.3 years) or healthy weight (n = 16, seven males, aged 26.3 ± 8.5 years). A brain stimulation protocol known as continuous theta burst transcranial magnetic stimulation was applied to the motor cortex to induce a brief suppression of cortical excitability. The suppression of cortical excitability was quantified using single-pulse transcranial magnetic stimulation to record and measure the amplitude of the motor evoked potential in a peripheral hand muscle. Therefore, the magnitude of suppression of the motor evoked potential by continuous theta burst stimulation was used as a measure of the capacity for plasticity of the motor cortex. Our results demonstrate that the healthy-weight group had a significant suppression of cortical excitability following continuous theta burst stimulation (cTBS), but there was no change in excitability for the obese group. Comparing the response to cTBS between groups demonstrated that there was an impaired plasticity response for the obese group when compared to the healthy-weight group. This might suggest that the capacity for plasticity is reduced in people who are obese. Given the importance of plasticity for human behaviour, our results add further emphasis to the potentially detrimental health effects of obesity.</jats:p>","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32839377","pmcid":"PMC7564681","openalex_id":"https://openalex.org/W3080902352","authors":[],"funders":[{"funder_name":"National Health and Medical Research Council (NHMRC)","grant_id":"1125054","title":"Characterising motor network connectivity to improve application of non-invasive brain stimulation in stroke"}],"total_grants":1,"fwci":0.9297,"citation_percentile":0.74875299,"influential_citations":0,"citation_trend":[{"year":2021,"count":5},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2076-3425/10/9/579/pdf?version=1598269751","host_type":"journal"},{"url":"https://www.mdpi.com/2076-3425/10/9/579/pdf?version=1598269751","host_type":"publisher"},{"url":"https://www.mdpi.com/2076-3425/10/9/579/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/brainsci10090579","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32839377","host_type":"repository"},{"url":"https://find.library.unisa.edu.au/discovery/fulldisplay/alma9916433885901831/61USOUTHAUS_INST:ROR","host_type":"repository"},{"url":"http://hdl.handle.net/2440/129420","host_type":"repository"},{"url":"https://doaj.org/article/38ac4625c1f44c28a6cce44771f6fcaa","host_type":"repository"},{"url":"https://figshare.com/articles/journal_contribution/Obesity_is_associated_with_reduced_plasticity_of_the_human_motor_cortex/20684089","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/brainsci10090579","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7564681","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7564681","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7564681?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.3390/brainsci10090579","host_type":""},{"url":"https://doi.org/https://doi.org/10.3390/brainsci10090579","host_type":""}],"fields_of_study":["Transcranial Magnetic Stimulation Studies","Muscle activation and electromyography studies","Neurological disorders and treatments","0301 basic medicine","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":[],"keywords":["CTBS","Transcranial magnetic stimulation","Motor cortex","Neuroplasticity","Stimulation","Neuroscience","Primary motor cortex","Psychology","Evoked potential","Medicine","Obesity","Theta burst stimulation","body mass index","Neurosciences. 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