{"doi":"10.3390/bios14020074","title":"High-Performance PMN-PT Single-Crystal-Based 1-3 Composite Transducer Integrated with a Biopsy Needle","abstract":"To address the need for high-resolution imaging in lung nodule detection and overcome the limitations of the shallow imaging depth associated with high-frequency ultrasound and the complex structure of lung tissue, we successfully integrated 50 MHz ultrasound transducers with 18-gauge biopsy needles. Featuring a miniaturized size of 0.6 × 0.5 × 0.5 mm3, the 50 MHz micromachined 1-3 composite transducer was tested to perform mechanical scanning of a nodule within a lung-tissue-mimicking phantom in vitro. The high-frequency transducer demonstrated the ability to achieve imaging with an axial resolution of 30 μm for measuring nodule edges. Moreover, the integrated biopsy needle prototype exhibited high accuracy (1.74% discrepancy) in estimating nodule area compared to actual dimensions in vitro. These results underscore the promising potential of biopsy-needle-integrated transducers in enhancing the accuracy of endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNA) for clinical applications.","journal":"Biosensors","year":2024,"id":444112,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.948,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":502782,"name":"Huaiyu Wu","orcid":"0000-0003-2616-1171","position":1,"is_corresponding":false},{"id":533450,"name":"Wei-Yi Chang","orcid":"0000-0003-1000-8121","position":2,"is_corresponding":false},{"id":369242,"name":"Sunho Moon","orcid":"0000-0001-6059-171X","position":3,"is_corresponding":false},{"id":1259661,"name":"Josh Mitchell","orcid":null,"position":4,"is_corresponding":false},{"id":631070,"name":"Chang Peng","orcid":"0000-0002-9495-1573","position":5,"is_corresponding":false},{"id":916662,"name":"Chih-Chung Huang","orcid":"0000-0003-3482-2646","position":6,"is_corresponding":false},{"id":512406,"name":"Marie Müller","orcid":"0000-0002-5662-0650","position":7,"is_corresponding":false},{"id":1259258,"name":"Jian Tian","orcid":"0000-0003-0521-6890","position":8,"is_corresponding":false},{"id":325196,"name":"Xiaoning Jiang","orcid":"0000-0003-3605-3801","position":9,"is_corresponding":false},{"id":1259660,"name":"Benjamin C. Kreager","orcid":null,"position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-19T02:01:33.526738Z","pmid":"38391993","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}