{"doi":"10.3390/biom15040482","title":"Platelet-Sourced TGF-β Promotes Th17 Responses and Enhances Airway Neutrophilia","abstract":"Microbial, especially fungal, sensitization has been associated with the development and exacerbation of treatment-refractory neutrophilic asthma. Among the airway-inhabiting fungi, Aspergillus fumigatus and Candida albicans are the dominant species that elicit protective T helper (Th) 17 and other T cell responses, contributing to airway neutrophilia and steroid resistance. However, it is not fully understood how fungal airway colonization impacts the immunopathogenesis of asthma. Here, we used a neutrophilic asthma model induced by C. albicans to study the immune regulation of this disease. We found that intranasal administration of C. albicans induced platelet infiltration into the lung. Platelet-expressed latent TGF-β could be activated specifically by Th17 cells and drive the commitment, maintenance, and expansion of Th17 cells. In Candida-induced asthma, an adoptive transfer of platelets enhanced Th17 responses, increasing airway neutrophil influx. Thus, managing airway mycobiota and reducing platelet intrapulmonary infiltration may serve as a promising interventional approach.","journal":"Biomolecules","year":2025,"id":563381,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9475,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":108098,"name":"Dandan Wu","orcid":"0000-0003-2073-5998","position":1,"is_corresponding":false},{"id":842204,"name":"Chunqing Wang","orcid":"0000-0002-2811-7230","position":2,"is_corresponding":false},{"id":1172503,"name":"Amanda Livingston","orcid":null,"position":3,"is_corresponding":false},{"id":385399,"name":"Xiang Wu","orcid":"0000-0002-9393-1052","position":4,"is_corresponding":false},{"id":281819,"name":"Meilian Liu","orcid":"0000-0003-1639-262X","position":5,"is_corresponding":false},{"id":108099,"name":"Xuexian O. Yang","orcid":"0000-0001-6816-7024","position":6,"is_corresponding":false},{"id":1466136,"name":"R. Wang","orcid":"0000-0002-9716-3089","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T02:56:13.374766Z","pmid":"40305199","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}