{"doi":"10.3390/biom13010008","title":"Sex-Specific Differences in Cytokine Induction by the Glycolipid Adjuvant 7DW8-5 in Mice","abstract":"7DW8-5 is a potent glycolipid adjuvant that improves malaria vaccine efficacy in mice by inducing IFN-γ and increasing protective CD8+ T cell responses. The addition of 7DW8-5 was previously shown to improve the efficacy of a CD8+ T cell-mediated heterologous ‘prime-and-trap’ malaria vaccine against Plasmodium yoelii sporozoite challenge in inbred female mice. Here, we report significant differential sex-specific responses to 7DW8-5 in inbred and outbred mice. Male mice express significantly less IFN-γ and IL-4 compared to females following intravenous 7DW8-5 administration. Additionally, unlike in female mice, 7DW8-5 did not improve the vaccine efficacy against sporozoite challenge in prime-and-trap vaccinated male mice. Our findings highlight the importance of including both female and male sexes in experimental adjuvant studies.","journal":"Biomolecules","year":2022,"id":288448,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9499,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":720489,"name":"Caroline J. Duncombe","orcid":"0000-0002-4356-6317","position":1,"is_corresponding":false},{"id":909966,"name":"Anya C. Kalata","orcid":null,"position":2,"is_corresponding":false},{"id":969252,"name":"Ethan Conrad","orcid":"0000-0002-4958-7274","position":3,"is_corresponding":false},{"id":561831,"name":"Sumana Chakravarty","orcid":"0000-0002-0426-6418","position":4,"is_corresponding":false},{"id":290873,"name":"B. Kim Lee Sim","orcid":"0000-0002-8598-8905","position":5,"is_corresponding":false},{"id":290874,"name":"Stephen L. Hoffman","orcid":"0000-0002-0700-9505","position":6,"is_corresponding":false},{"id":500709,"name":"Moriya Tsuji","orcid":"0000-0001-8587-277X","position":7,"is_corresponding":false},{"id":424275,"name":"Melanie J. Shears","orcid":"0000-0002-8226-4354","position":8,"is_corresponding":false},{"id":424276,"name":"Sean C. Murphy","orcid":"0000-0002-2048-0131","position":9,"is_corresponding":false},{"id":632998,"name":"Felicia Watson","orcid":"0000-0003-1468-5648","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:30:14.968626Z","pmid":"36671393","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}