{"doi":"10.3390/biom12091273","title":"New Insights into the Alveolar Epithelium as a Driver of Acute Respiratory Distress Syndrome","abstract":"The alveolar epithelium serves as a barrier between the body and the external environment. To maintain efficient gas exchange, the alveolar epithelium has evolved to withstand and rapidly respond to an assortment of inhaled, injury-inducing stimuli. However, alveolar damage can lead to loss of alveolar fluid barrier function and exuberant, non-resolving inflammation that manifests clinically as acute respiratory distress syndrome (ARDS). This review discusses recent discoveries related to mechanisms of alveolar homeostasis, injury, repair, and regeneration, with a contemporary emphasis on virus-induced lung injury. In addition, we address new insights into how the alveolar epithelium coordinates injury-induced lung inflammation and review maladaptive lung responses to alveolar damage that drive ARDS and pathologic lung remodeling.","journal":"Biomolecules","year":2022,"id":249047,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.95,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":889113,"name":"Sarah K. Moore","orcid":"0000-0003-2203-6568","position":1,"is_corresponding":false},{"id":84465,"name":"Peter Chen","orcid":"0000-0002-5330-1718","position":2,"is_corresponding":false},{"id":811519,"name":"Andrew Beppu","orcid":"0000-0001-9129-9535","position":3,"is_corresponding":false},{"id":848253,"name":"Jaime L. Hook","orcid":"0000-0002-6630-0060","position":4,"is_corresponding":false},{"id":569762,"name":"Marilia Sanches Santos Rizzo Zuttion","orcid":"0000-0002-0185-9074","position":0,"is_corresponding":true}],"reference_count":198,"raw_metadata":null,"created_at":"2026-07-19T00:24:19.356023Z","pmid":"36139112","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}