{"doi":"10.3390/biom12081083","title":"Vitamin A Deficiency Alters the Phototransduction Machinery and Distinct Non-Vision-Specific Pathways in the Drosophila Eye Proteome","abstract":"The requirement of vitamin A for the synthesis of the visual chromophore and the light-sensing pigments has been studied in vertebrate and invertebrate model organisms. To identify the molecular mechanisms that orchestrate the ocular response to vitamin A deprivation, we took advantage of the fact that Drosophila melanogaster predominantly requires vitamin A for vision, but not for development or survival. We analyzed the impacts of vitamin A deficiency on the morphology, the lipidome, and the proteome of the Drosophila eye. We found that chronic vitamin A deprivation damaged the light-sensing compartments and caused a dramatic loss of visual pigments, but also decreased the molar abundance of most phototransduction proteins that amplify and transduce the visual signal. Unexpectedly, vitamin A deficiency also decreased the abundances of specific subunits of mitochondrial TCA cycle and respiratory chain components but increased the levels of cuticle- and lens-related proteins. In contrast, we found no apparent effects of vitamin A deficiency on the ocular lipidome. In summary, chronic vitamin A deficiency decreases the levels of most components of the visual signaling pathway, but also affects molecular pathways that are not vision-specific and whose mechanistic connection to vitamin A remains to be elucidated.","journal":"Biomolecules","year":2022,"id":273024,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":109950,"name":"Canan Has","orcid":"0000-0003-2355-3727","position":1,"is_corresponding":false},{"id":662688,"name":"Khanh Lam‐Kamath","orcid":null,"position":2,"is_corresponding":false},{"id":914452,"name":"Sophie Ayciriex","orcid":"0000-0003-4813-5900","position":3,"is_corresponding":false},{"id":661958,"name":"Deepshe Dewett","orcid":"0000-0002-1022-5268","position":4,"is_corresponding":false},{"id":940552,"name":"Mhamed Bashir","orcid":null,"position":5,"is_corresponding":false},{"id":661959,"name":"Clara Poupault","orcid":"0000-0003-3145-9773","position":6,"is_corresponding":false},{"id":940006,"name":"Kai Schuhmann","orcid":"0000-0001-9776-7141","position":7,"is_corresponding":false},{"id":710242,"name":"Oskar Knittelfelder","orcid":"0000-0002-1565-7238","position":8,"is_corresponding":false},{"id":940007,"name":"Bharath Kumar Raghuraman","orcid":"0000-0003-1633-5836","position":9,"is_corresponding":false},{"id":377289,"name":"Robert Ahrends","orcid":"0000-0003-0232-3375","position":10,"is_corresponding":false},{"id":661961,"name":"Jens Rister","orcid":"0000-0002-0023-7417","position":11,"is_corresponding":false},{"id":14857,"name":"Andrej Shevchenko","orcid":"0000-0002-5079-1109","position":12,"is_corresponding":false},{"id":109105,"name":"Mukesh Kumar","orcid":"0000-0002-3578-3506","position":0,"is_corresponding":true}],"reference_count":97,"raw_metadata":null,"created_at":"2026-07-19T00:27:52.048702Z","pmid":"36008977","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}