{"doi":"10.3390/biom12030416","title":"Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases","abstract":"Maintenance of protein homeostasis is crucial for virtually every aspect of eukaryotic biology. The ubiquitin-proteasome system (UPS) represents a highly regulated quality control machinery that protects cells from a variety of stress conditions as well as toxic proteins. A large body of evidence has shown that UPS dysfunction contributes to the pathogenesis of cardiovascular diseases. This review highlights the latest findings regarding the physiological and pathological roles of cullin-RING ubiquitin ligases (CRLs), an essential player in the UPS, in the cardiovascular system. To inspire potential therapeutic invention, factors regulating CRL activities are also discussed.","journal":"Biomolecules","year":2022,"id":251724,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9463,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":738385,"name":"Kankan Wang","orcid":"0000-0002-7536-3338","position":1,"is_corresponding":false},{"id":620343,"name":"Benita Sjögren","orcid":"0000-0003-1460-1045","position":2,"is_corresponding":false},{"id":738386,"name":"Xing Liu","orcid":"0000-0001-9677-4470","position":3,"is_corresponding":false},{"id":738383,"name":"Stephanie Diaz","orcid":"0000-0002-0871-0563","position":0,"is_corresponding":true}],"reference_count":237,"raw_metadata":null,"created_at":"2026-07-19T00:24:41.993282Z","pmid":"35327608","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}