{"doi":"10.3390/biom12020227","title":"Viral dUTPases: Modulators of Innate Immunity","abstract":"Most free-living organisms encode for a deoxyuridine triphosphate nucleotidohydrolase (dUTPase; EC 3.6.1.23). dUTPases represent a family of metalloenzymes that catalyze the hydrolysis of dUTP to dUMP and pyrophosphate, preventing dUTP from being incorporated into DNA by DNA polymerases, maintaining a low dUTP/dTTP pool ratio and providing a necessary precursor for dTTP biosynthesis. Thus, dUTPases are involved in maintaining genomic integrity by preventing the uracilation of DNA. Many DNA-containing viruses, which infect mammals also encode for a dUTPase. This review will summarize studies demonstrating that, in addition to their classical enzymatic activity, some dUTPases possess novel functions that modulate the host innate immune response.","journal":"Biomolecules","year":2022,"id":270577,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9481,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":870831,"name":"Brandon Cox","orcid":null,"position":1,"is_corresponding":false},{"id":886742,"name":"Britney Martinez","orcid":"0000-0003-2206-4307","position":2,"is_corresponding":false},{"id":870419,"name":"Irene Mena-Palomo","orcid":"0000-0003-1200-1599","position":3,"is_corresponding":false},{"id":935338,"name":"Gloria Jeronimo Zarate","orcid":null,"position":4,"is_corresponding":false},{"id":934835,"name":"Marshall V. Williams","orcid":"0000-0003-2356-4725","position":5,"is_corresponding":false},{"id":554419,"name":"Maria E. Ariza","orcid":"0000-0003-2560-5367","position":0,"is_corresponding":true}],"reference_count":144,"raw_metadata":null,"created_at":"2026-07-19T00:27:31.019242Z","pmid":"35204728","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}