{"doi":"10.3390/biom11101484","title":"Sex Hormone-Binding Globulin (SHBG) in Cerebrospinal Fluid Does Not Discriminate between the Main FTLD Pathological Subtypes but Correlates with Cognitive Decline in FTLD Tauopathies","abstract":"Biomarkers to discriminate the main pathologies underlying frontotemporal lobar degeneration (FTLD-Tau, FTLD-TDP) are lacking. Our previous FTLD cerebrospinal fluid (CSF) proteome study revealed that sex hormone-binding globulin (SHBG) was specifically increased in FTLD-Tau patients. Here we investigated the potential of CSF SHBG as a novel biomarker discriminating the main FTLD pathological subtypes. SHBG was measured in CSF samples from patients with FTLD-Tau (n = 23), FTLD-TDP (n = 29) and controls (n = 33) using an automated electro-chemiluminescent immunoassay. Differences in CSF SHBG levels across groups, as well as its association with CSF YKL40, pTau181/total-Tau ratio and cognitive function were analyzed. CSF SHBG did not differ across groups, though a trend towards elevated levels in FTLD-Tau cases compared to FTLD-TDP and controls was observed. CSF SHBG levels were not associated with either CSF YKL40 or the p/tTau ratio. They, however, inversely correlated with the MMSE score (r = −0.307, p = 0.011), an association likely driven by the FTLD-Tau group (r FTLD-Tau = −0.38; r FTLD-TDP = −0.02). CSF SHBG is not a suitable biomarker to discriminate FTLD-Tau from FTLD-TDP.","journal":"Biomolecules","year":2021,"id":206963,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9609,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":233807,"name":"Yolande A.L. Pijnenburg","orcid":"0000-0003-2464-1905","position":1,"is_corresponding":false},{"id":76194,"name":"Alice S. Chen-Plotkin","orcid":"0000-0002-3387-2038","position":2,"is_corresponding":false},{"id":227417,"name":"David J. Irwin","orcid":"0000-0002-5599-5098","position":3,"is_corresponding":false},{"id":58510,"name":"Murray Grossman","orcid":"0000-0002-7447-6218","position":4,"is_corresponding":false},{"id":792523,"name":"Harry Twaalfhoven","orcid":null,"position":5,"is_corresponding":false},{"id":108302,"name":"William T. Hu","orcid":"0000-0003-4862-6777","position":6,"is_corresponding":false},{"id":652179,"name":"Lieke Meeter","orcid":"0000-0003-4277-0815","position":7,"is_corresponding":false},{"id":233804,"name":"John C. van Swieten","orcid":"0000-0001-6278-6844","position":8,"is_corresponding":false},{"id":370974,"name":"Lisa Vermunt","orcid":"0000-0001-7420-6384","position":9,"is_corresponding":false},{"id":791964,"name":"Frans Martens","orcid":"0000-0002-0670-4119","position":10,"is_corresponding":false},{"id":328217,"name":"Annemieke C. Heijboer","orcid":"0000-0002-6712-9955","position":11,"is_corresponding":false},{"id":242552,"name":"Charlotte E. Teunissen","orcid":"0000-0002-4061-0837","position":12,"is_corresponding":false},{"id":791963,"name":"Marta del Campo","orcid":"0000-0003-2808-3699","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-18T23:51:45.688025Z","pmid":"34680117","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}