{"doi":"10.3390/bioengineering13020166","title":"Feasibility of Golden Angle Spiral Real-Time Phase Contrast MRI at 0.55T: A Single-Center Prospective Study","abstract":"<jats:p>Background: Real-time phase-contrast magnetic resonance (RT-PCMR) imaging allows free-breathing assessment of blood flow across cardiac valves and vessels. However, the feasibility of free-breathing RT-PCMR on a mid-field (0.55T) MRI system has yet to be established. Aim: The primary objective of this study was to implement a RT-PCMR sequence using a dual-density golden-angle spiral readout with SENSE-based compressed sensing (CS) reconstruction on a 0.55T MRI system. The secondary objective was to evaluate the feasibility of this approach in an adult cohort comprising healthy volunteers and patients with cardiovascular disease. Materials and Methods: Data from 33 participants were included in the flow quantification analysis (healthy volunteers: n = 17, 9 females, mean age 30.4 ± 14.6 years; patients: n = 16, 11 females, mean age 45.9 ± 17.4 years), with breath-held (BH) segmented Cartesian PCMR used as the reference standard. Results: In volunteers, RT-PCMR showed good agreement for net flow, peak flow rate, and pulmonary–systemic flow ratio (Qp/Qs), without significant bias (p &gt; 0.05) and slightly underestimated peak velocity [7.9% in the aorta and 8.6% in the main pulmonary artery (MPA)]. In patients, RT-PCMR slightly underestimated peak flow rate (aorta, 6.2%; MPA; 4.6%) and peak velocity (aorta,12.7%; MPA, 10.4%). A sub-analysis of six patients scanned at both 0.55T and 3T showed close agreement between field strengths. Conclusions: These results demonstrate the feasibility of our RT-PCMR sequence on a commercial 0.55T system.</jats:p>","journal":"Bioengineering","year":2026,"id":653961,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":993247,"name":"Chong Chen","orcid":"0000-0002-5035-4021","position":1,"is_corresponding":false},{"id":1040743,"name":"Yingmin Liu","orcid":"0000-0001-5886-8636","position":2,"is_corresponding":false},{"id":770621,"name":"Katherine Binzel","orcid":"0000-0001-9439-3367","position":3,"is_corresponding":false},{"id":342550,"name":"Kelvin Chow","orcid":"0000-0003-0698-1746","position":4,"is_corresponding":false},{"id":238108,"name":"Rizwan Ahmad","orcid":"0000-0002-5917-3788","position":5,"is_corresponding":false},{"id":329908,"name":"Yuchi Han","orcid":"0000-0001-7582-1848","position":6,"is_corresponding":false},{"id":307116,"name":"Orlando P. Simonetti","orcid":"0000-0002-8994-0095","position":7,"is_corresponding":false},{"id":301733,"name":"Ning Jin","orcid":"0000-0002-6689-4671","position":8,"is_corresponding":false},{"id":842314,"name":"Juliet Varghese","orcid":"0000-0003-2882-2893","position":9,"is_corresponding":false},{"id":1706560,"name":"Salman Pervaiz","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Feasibility of Golden Angle Spiral Real-Time Phase Contrast MRI at 0.55T: A Single-Center Prospective Study","abstract":"<jats:p>Background: Real-time phase-contrast magnetic resonance (RT-PCMR) imaging allows free-breathing assessment of blood flow across cardiac valves and vessels. However, the feasibility of free-breathing RT-PCMR on a mid-field (0.55T) MRI system has yet to be established. Aim: The primary objective of this study was to implement a RT-PCMR sequence using a dual-density golden-angle spiral readout with SENSE-based compressed sensing (CS) reconstruction on a 0.55T MRI system. The secondary objective was to evaluate the feasibility of this approach in an adult cohort comprising healthy volunteers and patients with cardiovascular disease. Materials and Methods: Data from 33 participants were included in the flow quantification analysis (healthy volunteers: n = 17, 9 females, mean age 30.4 ± 14.6 years; patients: n = 16, 11 females, mean age 45.9 ± 17.4 years), with breath-held (BH) segmented Cartesian PCMR used as the reference standard. Results: In volunteers, RT-PCMR showed good agreement for net flow, peak flow rate, and pulmonary–systemic flow ratio (Qp/Qs), without significant bias (p &gt; 0.05) and slightly underestimated peak velocity [7.9% in the aorta and 8.6% in the main pulmonary artery (MPA)]. In patients, RT-PCMR slightly underestimated peak flow rate (aorta, 6.2%; MPA; 4.6%) and peak velocity (aorta,12.7%; MPA, 10.4%). A sub-analysis of six patients scanned at both 0.55T and 3T showed close agreement between field strengths. Conclusions: These results demonstrate the feasibility of our RT-PCMR sequence on a commercial 0.55T system.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41749707","pmcid":"PMC12938216","openalex_id":"https://openalex.org/W7126069477","authors":[],"funders":[{"funder_name":"National Heart, Lung, and Blood Institute of the National Institutes of Health","grant_id":"R01HL161618","title":null},{"funder_name":"National Heart, Lung, and Blood Institute of the National Institutes of Health","grant_id":"R01HL151697","title":null},{"funder_name":"Siemens Healthcare (United States)","grant_id":"Institutional Research Support.","title":null},{"funder_name":"Robert F. Wolfe and Edgar T. Wolfe Foundation","grant_id":"Orlando P Simonetti is supported.","title":null}],"total_grants":4,"fwci":0.0,"citation_percentile":0.08508856,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2306-5354/13/2/166/pdf?version=1769678971","host_type":"journal"},{"url":"https://www.mdpi.com/2306-5354/13/2/166/pdf?version=1769678971","host_type":"publisher"},{"url":"https://www.mdpi.com/2306-5354/13/2/166/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/bioengineering13020166","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41749707","host_type":"repository"},{"url":"https://doaj.org/article/ffd83b4e9ff448d0aaadf886a5bf9a60","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12938216/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12938216","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12938216?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Advanced MRI Techniques and Applications","Cardiac Imaging and Diagnostics","Atomic and Subatomic Physics Research"],"mesh_terms":[],"keywords":["Spiral (railway)","Magnetic resonance imaging","Prospective cohort study","Blood flow","Phase contrast microscopy","Flow (mathematics)","Aorta","Volumetric flow rate","Compressed Sensing","Phase-contrast","Flow Imaging","Real-time Mri","Spiral Acquisition","Mid Field"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T02:25:18.498139Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}