{"doi":"10.3390/bioengineering12080859","title":"Mitomycin C in Ahmed Glaucoma Valve Implant Affects Surgical Outcomes","abstract":"Glaucoma is the leading cause of irreversible blindness worldwide, and the Ahmed Glaucoma Valve (AGV) implant is one of the most commonly performed surgeries to prevent glaucoma-related visual impairment. Mitomycin C is an anti-fibrotic agent that may prevent failure of AGV. This is a retrospective case–control study to evaluate surgical outcomes for patients undergoing AGV with adjunct mitomycin C (MMC) injections compared to those without MMC. Among the 142 eyes, 50 received adjunct MMC compared to 92 without MMC injections. IOPs at post-operative months 1, 3, and 6 were significantly lower in the MMC eyes (9.40, 12.01, 12.63 mmHg) compared to the No-MMC eyes (16.86, 15.87, 15.65 mmHg; p < 0.01). The number of post-operative glaucoma medications for the MMC group was lower at 1, 3, and 6 months (0.3, 0.4, 0.59) compared to the No-MMC group (0.7, 0.97, 1.05; p < 0.05). The difference in IOP and the number of medications was not statistically significant by 12 months. Adjunct MMC was associated with more transient hypotony but no long-term complications. These findings suggest that adjunct MMC improves short-term but not long-term surgical outcomes in AGV glaucoma implants.","journal":"Bioengineering","year":2025,"id":542092,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9576,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":977621,"name":"Sen Yang","orcid":"0000-0002-0091-7498","position":1,"is_corresponding":false},{"id":264174,"name":"Michelle R. Hribar","orcid":"0000-0003-1724-1858","position":2,"is_corresponding":false},{"id":796196,"name":"Aiyin Chen","orcid":"0000-0002-2125-948X","position":3,"is_corresponding":false},{"id":796195,"name":"Wei-Chun Lin","orcid":"0000-0002-0439-0347","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T02:52:51.593043Z","pmid":"40868372","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}