{"doi":"10.3390/bioengineering12080814","title":"Unveiling Early Signs of Preclinical Alzheimer's Disease Through ERP Analysis with Weighted Visibility Graphs and Ensemble Learning.","abstract":"-tests to reduce noise. Subsequent statistical analysis reveals significant disparities in the structure of WVG networks between preAD and normal subjects. Furthermore, Principal Component Analysis (PCA) was applied to condense the input data into its principal features. Leveraging these PCA components as input features, several machine learning algorithms are used to classify preAD vs. normal subjects. To enhance classification accuracy and robustness, an ensemble method is employed alongside the classifiers. Our framework achieved an accuracy of up to 92% discriminating preAD from normal old using both linear and non-linear classifiers, signifying the efficacy of combining WVG and ensemble learning in identifying very early AD from EEG signals. The framework can also improve clinical efficiency by reducing the amount of data required for effective classification and thus saving valuable clinical time.","journal":"PubMed","year":2025,"id":571644,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9562,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":868939,"name":"Jiangyi Xia","orcid":"0000-0002-2246-2631","position":1,"is_corresponding":false},{"id":1478025,"name":"Ziwen Kan","orcid":null,"position":2,"is_corresponding":false},{"id":1478026,"name":"Jesse Zhang","orcid":null,"position":3,"is_corresponding":false},{"id":1477748,"name":"Sheela Toprani","orcid":"0000-0002-4960-0168","position":4,"is_corresponding":false},{"id":66463,"name":"James Brewer","orcid":null,"position":5,"is_corresponding":false},{"id":342257,"name":"Marta Kutas","orcid":"0000-0002-3689-5825","position":6,"is_corresponding":false},{"id":1477749,"name":"Xin Liu","orcid":"0000-0002-5379-8269","position":7,"is_corresponding":false},{"id":303071,"name":"John Olichney","orcid":null,"position":8,"is_corresponding":false},{"id":1477747,"name":"Yongshuai Liu","orcid":"0000-0002-9629-0393","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T02:57:19.669553Z","pmid":"40868327","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}