{"doi":"10.3390/app15095061","title":"Alkali-Treated, Nanostructured-Micro-Porous Titanium Surfaces Enhance Osteogenic Differentiation of Adipose Derived Stem Cells","abstract":"Ensuring effective integration between the material of an implant and bone is critical to orthopedic implants’ success in the long term. A major issue with dense materials is the mechanical mismatch between them and the bone, which leads to improper osseointegration. Porous implants have presented a solution to this issue as they are able to retain material properties in addition to decreasing mismatches. In order to make implants more biomimetic and to match the micro-/nano hierarchy of bone, several surface modifications have been explored in the literature. Hydrothermal treatment in an alkali media on dense titanium has demonstrated higher differentiation of adipose-derived stem cells to osteogenic lineages. In this study, we fabricated nanostructures using hydrothermal treatment in an alkali medium on micro-porous titanium surfaces and evaluated the adhesion, proliferation, and differentiation of adipose derived stem cells to osteoblasts. The nanostructured-micro-porous titanium surfaces displayed enhanced osteogenic differentiation of adipose derived stem cells. Therefore, they have the potential to be used as surfaces for the fabrication of orthopedic implants.","journal":"Applied Sciences","year":2025,"id":523254,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1396185,"name":"Emma Holloway","orcid":null,"position":1,"is_corresponding":false},{"id":312680,"name":"Ketul C. Popat","orcid":"0000-0002-2417-7789","position":2,"is_corresponding":false},{"id":1083681,"name":"Aniruddha Vijay Savargaonkar","orcid":"0009-0005-2680-2233","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T02:50:03.004175Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}