{"doi":"10.3390/antiox13080983","title":"Curcumin Supplementation and Vascular and Cognitive Function in Chronic Kidney Disease: A Randomized Controlled Trial","abstract":"Chronic kidney disease (CKD) increases the risk of cardiovascular disease and cognitive impairment. Curcumin is a polyphenol that improves vascular and cognitive function in older adults; however, its effects on vascular and cognitive function in patients with CKD are unknown. We hypothesized that curcumin supplementation would improve vascular and cognitive function in patients with CKD. Eighty-eight adults diagnosed with stage 3b or 4 CKD (aged 66 ± 8 years, 75% male) participated in a 12-month, randomized, double-blind, placebo-controlled study to test the effects of curcumin (Longvida®, 2000 mg/day) on vascular and cognitive function. Our primary outcome was brachial artery flow-mediated dilation (FMD). Our secondary outcomes were nitroglycerin-mediated dilation, carotid–femoral pulse wave velocity (cfPWV), and cognitive function assessed via the NIH Toolbox Cognition Battery. At baseline, the mean estimated glomerular filtration rate was 34.7 ± 10.8, and the median albumin/creatinine ratio was 81.9 (9.7, 417.3). A total of 44% of participants had diabetes. Compared with placebo, 12 months of curcumin did not improve FMD (median change from baseline was −0.7 (−2.1, 1.1) and −0.1 (−1.5, 1.5) for curcumin and placebo, respectively, with p = 0.69). Similarly, there were no changes in nitroglycerin-mediated dilation, cfPWV, or cognitive outcomes. These results do not support chronic curcumin supplementation to improve vascular and cognitive function in patients with CKD.","journal":"Antioxidants","year":2024,"id":445287,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":372949,"name":"Nicholas T. Kruse","orcid":null,"position":1,"is_corresponding":false},{"id":706613,"name":"Katharine Geasland","orcid":"0000-0002-8807-0702","position":2,"is_corresponding":false},{"id":1050379,"name":"Jeni Michelson","orcid":null,"position":3,"is_corresponding":false},{"id":701885,"name":"Mingyao Sun","orcid":"0000-0001-5306-986X","position":4,"is_corresponding":false},{"id":274745,"name":"Patrick Ten Eyck","orcid":"0000-0002-5041-0708","position":5,"is_corresponding":false},{"id":1261733,"name":"Cari Linkenmeyer","orcid":null,"position":6,"is_corresponding":false},{"id":1050380,"name":"Safur Rehman Mandukhail","orcid":null,"position":7,"is_corresponding":false},{"id":315365,"name":"Matthew J. Rossman","orcid":"0000-0001-9381-2590","position":8,"is_corresponding":false},{"id":1050895,"name":"Meenakshi Sambharia","orcid":"0000-0001-5374-9590","position":9,"is_corresponding":false},{"id":110793,"name":"Michel Chonchol","orcid":null,"position":10,"is_corresponding":false},{"id":295976,"name":"Manjula Kurella Tamura","orcid":"0000-0001-5227-2479","position":11,"is_corresponding":false},{"id":307108,"name":"Douglas R. Seals","orcid":"0000-0002-2391-9824","position":12,"is_corresponding":false},{"id":24973,"name":"Karin F. Hoth","orcid":"0000-0002-4261-5308","position":13,"is_corresponding":false},{"id":232869,"name":"Diana Jalal","orcid":"0000-0002-1975-8650","position":14,"is_corresponding":false},{"id":1049876,"name":"Colin J. Gimblet","orcid":"0000-0002-3024-2284","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T02:01:42.089235Z","pmid":"39199229","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}