{"doi":"10.3390/antiox10081175","title":"GLP-1 Analog Liraglutide Improves Vascular Function in Polymicrobial Sepsis by Reduction of Oxidative Stress and Inflammation","abstract":"Sepsis causes high mortality in the setting of septic shock. LEADER and other trials revealed cardioprotective and anti-inflammatory properties of glucagon-like peptide-1 (GLP-1) analogs like liraglutide (Lira). We previously demonstrated improved survival in lipopolysaccharide (LPS)-induced endotoxemia by inhibition of GLP-1 degradation. Here we investigate the effects of Lira in the polymicrobial sepsis model of cecal ligation and puncture (CLP). C57BL/6J mice were intraperitoneally injected with Lira (200 µg/kg/d; 3 days) and sepsis induced by CLP after one day of GLP-1 analog treatment. Survival and body temperature were monitored. Aortic vascular function (isometric tension recording), protein expression (immunohistochemistry and dot blot) and gene expression (qRT-PCR) were determined. Endothelium-dependent relaxation in the aorta was impaired by CLP and correlated with markers of inflammation (e.g., interleukin 6 and inducible nitric oxide synthase) and oxidative stress (e.g., 3-nitrotyrosine) was higher in septic mice, all of which was almost completely normalized by Lira therapy. We demonstrate that the GLP-1 analog Lira ameliorates sepsis-induced endothelial dysfunction by the reduction of vascular inflammation and oxidative stress. Accordingly, the findings suggest that the antioxidant and anti-inflammatory effects of GLP-1 analogs may be a valuable tool to protect the cardiovascular system from dysbalanced inflammation in polymicrobial sepsis.","journal":"Antioxidants","year":2021,"id":157479,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":50,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":664569,"name":"Karin Keppeler","orcid":"0000-0002-8100-8885","position":1,"is_corresponding":false},{"id":665491,"name":"Franziska Aust","orcid":null,"position":2,"is_corresponding":false},{"id":665492,"name":"Leonie Küster","orcid":null,"position":3,"is_corresponding":false},{"id":72043,"name":"Katie Frenis","orcid":"0000-0003-4103-0882","position":4,"is_corresponding":false},{"id":664570,"name":"Konstantina Filippou","orcid":"0000-0002-8256-8905","position":5,"is_corresponding":false},{"id":664571,"name":"Ksenija Vujačić-Mirski","orcid":"0000-0002-4800-4209","position":6,"is_corresponding":false},{"id":665493,"name":"Simeon Tsohataridis","orcid":null,"position":7,"is_corresponding":false},{"id":665494,"name":"Sanela Kalinovic","orcid":null,"position":8,"is_corresponding":false},{"id":664572,"name":"Swenja Kröller‐Schön","orcid":"0000-0001-6074-2119","position":9,"is_corresponding":false},{"id":664573,"name":"Matthias Oelze","orcid":"0000-0002-5939-7263","position":10,"is_corresponding":false},{"id":232297,"name":"Markus Bosmann","orcid":"0000-0003-2773-1033","position":11,"is_corresponding":false},{"id":272828,"name":"Thomas Münzel","orcid":null,"position":12,"is_corresponding":false},{"id":300904,"name":"Andreas Daiber","orcid":"0000-0002-2769-0094","position":13,"is_corresponding":false},{"id":664574,"name":"Sebastian Steven","orcid":"0000-0002-5332-9294","position":14,"is_corresponding":false},{"id":665490,"name":"Johanna Helmstädter","orcid":null,"position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-18T23:44:21.786014Z","pmid":"34439423","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}