{"doi":"10.3390/ani16030458","title":"Swine Enteric Coronaviruses: An Updated Overview of Epidemiology, Diagnosis, Prevention, and Control","abstract":"<jats:p>Swine enteric coronaviruses (SECoVs), including transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and swine acute diarrhea syndrome coronavirus (SADS-CoV), are major enteric pathogens causing severe diarrhea, dehydration, high neonatal mortality, and substantial global economic losses. Rapid viral evolution and recombination continually generate antigenically diverse variants that limit cross-protection and undermine vaccine efficacy, particularly for PEDV genogroup II strains that now dominate worldwide circulation. This review synthesizes current knowledge on epidemiology, diagnostic innovations, and emerging vaccine platforms, with emphasis on advances since 2022. Recent progress includes molecular surveillance tools, rapid point-of-care diagnostics, and next-generation vaccine technologies such as mRNA-based and virus-like particle platforms. However, significant knowledge gaps persist regarding viral evolution dynamics, co-infection synergies, and zoonotic spillover potential, particularly following documented human infections with PDCoV. Effective long-term control requires integrated genomic surveillance, strengthened farm-level biosecurity, rationally designed multivalent vaccines targeting conserved epitopes, and harmonized international surveillance systems to reduce outbreak risk and enhance pandemic preparedness at the human–animal interface.</jats:p>","journal":"Animals","year":2026,"id":637527,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1208268,"name":"Can Liu","orcid":"0000-0001-5521-3335","position":1,"is_corresponding":false},{"id":1655426,"name":"Yuandi Yu","orcid":null,"position":2,"is_corresponding":false},{"id":623708,"name":"Liu Yang","orcid":"0000-0002-9492-4508","position":3,"is_corresponding":false},{"id":1655427,"name":"Qianlin Chen","orcid":null,"position":4,"is_corresponding":false},{"id":104562,"name":"Wenjie Ma","orcid":"0000-0001-9894-7072","position":5,"is_corresponding":false},{"id":1655430,"name":"Gebremeskel Mamu Werid","orcid":"0000-0002-3189-1470","position":6,"is_corresponding":false},{"id":1655431,"name":"Shaomei Li","orcid":null,"position":7,"is_corresponding":false},{"id":351657,"name":"Jie Luo","orcid":"0000-0002-0543-4778","position":8,"is_corresponding":false},{"id":1655432,"name":"Shengbin Gao","orcid":null,"position":9,"is_corresponding":false},{"id":1655433,"name":"Suhui Zhang","orcid":null,"position":10,"is_corresponding":false},{"id":1655434,"name":"Lizhi Fu","orcid":null,"position":11,"is_corresponding":false},{"id":625826,"name":"Yue Wang","orcid":"0009-0005-4062-1316","position":12,"is_corresponding":false},{"id":1655425,"name":"Yassein M. 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This review synthesizes current knowledge on epidemiology, diagnostic innovations, and emerging vaccine platforms, with emphasis on advances since 2022. Recent progress includes molecular surveillance tools, rapid point-of-care diagnostics, and next-generation vaccine technologies such as mRNA-based and virus-like particle platforms. However, significant knowledge gaps persist regarding viral evolution dynamics, co-infection synergies, and zoonotic spillover potential, particularly following documented human infections with PDCoV. Effective long-term control requires integrated genomic surveillance, strengthened farm-level biosecurity, rationally designed multivalent vaccines targeting conserved epitopes, and harmonized international surveillance systems to reduce outbreak risk and enhance pandemic preparedness at the human–animal interface.</jats:p>","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41681438","pmcid":"PMC12897436","openalex_id":"https://openalex.org/W7127115481","authors":[],"funders":[{"funder_name":"National Center of Technology Innovation for Pigs","grant_id":"NCTIP–XD/B19","title":null},{"funder_name":"Chongqing Talent plan “contract system” project","grant_id":"cstc2022ycjh-bgzxm0183","title":null},{"funder_name":"Chongqing Talent plan “contract system” project","grant_id":"22509C","title":null},{"funder_name":"Sichuan Provincial Regional Innovation Cooperation Project","grant_id":"2024YFHZ0110","title":null},{"funder_name":"this work was supported by grants from the National Center of Technology Innovation for Pigs (NCTIP-XD/B19); the Chongqing Talent plan \"contract system\" project (cstc2022ycjh-bgzxm0183 and 22509C); the Sichuan Provincial Regional Innovation Cooperation Pr","grant_id":"(cstc2022ycjh-bgzxm0183 and 22509C) and (2024YFHZ0110)","title":null}],"total_grants":5,"fwci":30.6889,"citation_percentile":0.99774436,"influential_citations":0,"citation_trend":[{"year":2026,"count":5}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2076-2615/16/3/458/pdf?version=1769942988","host_type":"journal"},{"url":"https://www.mdpi.com/2076-2615/16/3/458/pdf?version=1769942988","host_type":"publisher"},{"url":"https://www.mdpi.com/2076-2615/16/3/458/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ani16030458","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41681438","host_type":"repository"},{"url":"https://doaj.org/article/0b2c7544add64d6281b15fc6ee394139","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12897436","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12897436/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12897436","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12897436?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Animal Virus Infections Studies","Viral gastroenteritis research and epidemiology","Animal Disease Management and Epidemiology"],"mesh_terms":[],"keywords":["Pandemic","Porcine epidemic diarrhea virus","Outbreak","Coronavirus","Preparedness","Norovirus","Coronavirus disease 2019 (COVID-19)","Diarrhea","Virus","Vaccines","epidemiology","Diagnostics","Cross-species Transmission","Biosecurity","Swine Enteric Coronaviruses"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T19:06:47.261141Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}