{"doi":"10.3389/fviro.2025.1600802","title":"IL-27 effects on HIVGag-specific CD4 and CD8 T cell function","abstract":"Background: In people with HIV (PWH) and suppressed viral replication by antiretroviral therapy persistent T cell activation and inflammation are important contributors of the increased risk of morbidity and mortality. CD8 T cells express checkpoint receptors and are dysfunctional. IL-27, a member of the IL-6/IL-12 family has shown anti-viral properties against various human viruses, including HIV. The role of IL-27 on HIV-specific T cells remains unclear. We hypothesized that IL-27 will enhance the function of HIV-specific T cells. Methods: IL-27 effects on T cell function was evaluated by measuring cytokine secretion, proliferation, and cytotoxicity. Results: Our findings show that IL-27 upregulates cytokine secretion and cytotoxic potential, and trafficking of proliferating HIV-specific CD8 T cells expressing checkpoint receptors TIGIT and PD-1. Unbiased clustering analysis showed that IL-27 may have differential effects on distinct populations of HIV-specific T cells. Conclusion: Altogether these results suggest that IL-27 may enhance T cell function in the setting of chronic HIV infection.","journal":"Frontiers in Virology","year":2025,"id":541380,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9655,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":967168,"name":"Grace Katz","orcid":null,"position":1,"is_corresponding":false},{"id":397795,"name":"Jie Cheng","orcid":"0000-0002-8835-3171","position":2,"is_corresponding":false},{"id":1359294,"name":"Chinmayee Mehta","orcid":null,"position":3,"is_corresponding":false},{"id":1235444,"name":"Fernando Andres-Martin","orcid":null,"position":4,"is_corresponding":false},{"id":1429726,"name":"Danish Mahmood","orcid":"0000-0003-0202-8691","position":5,"is_corresponding":false},{"id":444050,"name":"Princy Kumar","orcid":"0000-0002-5994-2727","position":6,"is_corresponding":false},{"id":474439,"name":"Marta Catálfamo","orcid":null,"position":7,"is_corresponding":false},{"id":967167,"name":"Maryam Abdussamad","orcid":null,"position":0,"is_corresponding":true}],"reference_count":94,"raw_metadata":null,"created_at":"2026-07-19T02:52:47.161928Z","pmid":"41393062","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}