{"doi":"10.3389/fviro.2022.869431","title":"Highly Efficient Autologous HIV-1 Isolation by Coculturing Macrophage With Enriched CD4+ T Cells From HIV-1 Patients","abstract":"We described a novel HIV autologous isolation method based in coculturing macrophages and CD4 + T-cell-enriched fractions from peripheral blood collected from antiretroviral-treated (ART) HIV patients. This method allows the isolation of high viral titers of autologous viruses, over 10 10 HIV RNA copies/ml, and reduces the time required to produce necessary amounts for virus for use as antigens presented by monocyte-derived myeloid cells in HIV therapeutic vaccine approaches. By applying these high titer and autologous virus produced in the patient-derived cells, we intended to elicit a boost of the immunological system response in HIV therapeutic vaccines in clinical trials.","journal":"Frontiers in Virology","year":2022,"id":308245,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":482211,"name":"Tània González","orcid":null,"position":1,"is_corresponding":false},{"id":974867,"name":"Lorna Leal","orcid":"0000-0001-7887-6027","position":2,"is_corresponding":false},{"id":744251,"name":"Charles M. Trubey","orcid":null,"position":3,"is_corresponding":false},{"id":233484,"name":"Jeffrey D. Lifson","orcid":"0000-0002-9494-0268","position":4,"is_corresponding":false},{"id":1003198,"name":"José María Gatell","orcid":null,"position":5,"is_corresponding":false},{"id":263025,"name":"José Alcamı́","orcid":"0000-0003-0023-7377","position":6,"is_corresponding":false},{"id":417416,"name":"Núria Climent","orcid":"0000-0002-0791-656X","position":7,"is_corresponding":false},{"id":974871,"name":"Felipe García","orcid":"0000-0001-7658-5832","position":8,"is_corresponding":false},{"id":861285,"name":"Sonsoles Sánchez‐Palomino","orcid":null,"position":9,"is_corresponding":false},{"id":1003197,"name":"Cristina Xufré","orcid":null,"position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:33:03.486542Z","pmid":"35967461","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}