{"doi":"10.3389/fvets.2024.1533052","title":"Editorial: Best practices in clinical research conduct in veterinary medicine","abstract":"Consensus statements play a key role in medical practice. They represent the combined recommendations of experts in the field, usually when there is a lack of comprehensive evidence available on a topic, and serve to translate available research findings into clinical practice recommendations. Although consensus statements have limitations and biases that should be considered, they can significantly influence patient treatment, health policy, and societal behavior (17). The impact of consensus statements on veterinary prescribing habits in clinical practice has not been fully evaluated, and Sainz et al. investigated the prevalence and appropriateness of omeprazole prescriptions in dogs at a veterinary teaching hospital before and after the publication of the 2018 American College of Veterinary Internal Medicine consensus statement on the rational administration of gastrointestinal protectants (18). The retrospective study compared the prescribing habits for the proton pump inhibitor omeprazole in dogs at an academic veterinary teaching hospital in the 12 months before and after the publication of the consensus statement. Although a small study, the results support the impact of the consensus statement on prescribing patterns for omeprazole in an academic veterinary hospital. Further investigation is needed to evaluate the impact of consensus statements in other practice environments and into other mechanisms to support appropriate medication prescription practices. Sample biobanking facilitates impactful research through collection, cataloging, and storage of control and diseased biological samples allowing timely sample analysis. However, biobanking has been associated with controversy (19), and lack of best practices led to a New York Times best-selling book and movie about the generation of HeLa cells -used widely in researchwithout patient consent (20). Veterinary biobanks support both human and veterinary clinical research, storing biological samples from animals with naturally occurring disease for future use and distribution to academic researchers and industry. However, informed consent provided by owners for pets contributing to biobanks can be complicated by limited understanding of goals, purpose, and logistics of biobanking. McEnhill et al. performed a survey-based study to investigate pet owner perspectives, motivators, and concerns about veterinary biobanking with the goal of identifying opportunities to improve education, awareness of veterinary biobanking initiatives, and consent processes. Study results suggest veterinary biobanking initiatives are well received by owners, most of whom are willing to allow their pets to participate, and respondent concerns represent opportunities for veterinary biobanks to improve messaging and dissemination of results from work they support. A successful clinical trial requires participants, but many factors can impede effective study recruitment. Quigley et al. provide guidelines on best practices for recruitment of patients to veterinary clinical trials. Strategies for recruitment of high-quality subjects for clinical research should utilize a holistic view of recruitment encompassing study design and logistics, representative participation, incentives, personnel resources, advertising, and participant retention. Although human clinical trial resources can provide guidance, effort also needs to be put into evaluating current practices and opportunities for process improvement that are specific to veterinary clinical trials.In September 2023, the United States Food and Drug Administration released a draft guidance for comment about how informed client consent for companion animal clinical trials should be obtained (3). Frederick provides a review of this document, focused on the implications for those conducting veterinary clinical research. The guidance for consent timeframe, language, and specific elements will involve additional efforts by investigators to ensure adherenc","journal":"Frontiers in Veterinary Science","year":2024,"id":507216,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9573,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":409840,"name":"Sarah A. Moore","orcid":"0000-0002-4311-6199","position":1,"is_corresponding":false},{"id":720578,"name":"Benjamin M. Brainard","orcid":"0000-0003-4299-2936","position":2,"is_corresponding":false},{"id":1155329,"name":"Tracy L. Webb","orcid":"0000-0003-4547-3787","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-19T02:10:58.484528Z","pmid":"39720404","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}