{"doi":"10.3389/fvets.2023.1255834","title":"Effectiveness of silver diamine fluoride 38% on reduction of gingivitis in dogs: a randomized clinical trial","abstract":"Introduction: Periodontal disease is a ubiquitous disease in small animal veterinary medicine. Currently regular professional dental cleaning and daily tooth brushing are considered gold standards in the prevention of periodontal disease. Efforts to find a noninvasive, cost effective and easy to use preventative for periodontal disease are ongoing. The primary objective of this double-blind randomized clinical trial was to determine if a single application of silver diamine fluoride (SDF) 38% on the buccal surface of all teeth would reduce gingivitis within 3 months in dogs with stage two periodontal disease. Methods: Twenty-nine client-owned dogs 3-12 years old, 6-35 pounds were randomized 1:1 into active and placebo-control groups. Both groups underwent a baseline treatment and a three-month follow-up under general anesthesia. Gingival Index (GI), Plaque Index (PI), and Calculus Index (CI) were assessed and recorded at each event. Results: A single application of SDF 38% did not significantly lower GI relative to the control group. However, the GI score dropped significantly in both groups relative to baseline, with a 53% reduction in the average GI score for dogs that received SDF 38% treatment and a 44% reduction for dogs that received placebo treatment. There were no differences in PI or CI scores compared to control groups. Conclusion: Further research is needed to determine if a more frequent application or a longer study duration would yield a different outcome.","journal":"Frontiers in Veterinary Science","year":2023,"id":385402,"datarank":0.19683722087951833,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.032045377579301856,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.032045377579301856,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":2,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1153449,"name":"Tammy Renteria","orcid":null,"position":1,"is_corresponding":false},{"id":1008279,"name":"Marilynn Rothen","orcid":"0000-0003-3109-3222","position":2,"is_corresponding":false},{"id":966123,"name":"Lloyd Mancl","orcid":"0000-0001-8566-8883","position":3,"is_corresponding":false},{"id":1153118,"name":"Peter Milgrom","orcid":"0000-0003-0784-9181","position":4,"is_corresponding":false},{"id":1153448,"name":"Amarett Kern","orcid":null,"position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:17:48.629718Z","pmid":"37799409","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}