{"doi":"10.3389/fvets.2022.908801","title":"Neuroimaging in the Epileptic Baboon","abstract":"<jats:p>Characterization of baboon model of genetic generalized epilepsy (GGE) is driven both electroclinically and by successful adoption of neuroimaging platforms, such as magnetic resonance imaging (MRI) and positron emission tomography (PET). Based upon its phylogenetic proximity and similar brain anatomy to humans, the epileptic baboon provides an excellent translational model. Its relatively large brain size compared to smaller nonhuman primates or rodents, a gyrencephalic structure compared to lissencephalic organization of rodent brains, and the availability of a large pedigreed colony allows exploration of neuroimaging markers of diseases. Similar to human idiopathic generalized epilepsy (IGE), structural imaging in the baboon is usually normal in individual subjects, but gray matter volume/concentration (GMV/GMC) changes are reported by statistical parametric mapping (SPM) analyses. Functional neuroimaging has been effective for mapping the photoepileptic responses, the epileptic network, altered functional connectivity of physiological networks, and the effects of anti-seizure therapies. This review will provide insights into our current understanding the baboon model of GGE through functional and structural imaging.</jats:p>","journal":"Frontiers in Veterinary Science","year":2022,"id":650823,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":760624,"name":"Felipe S. 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Similar to human idiopathic generalized epilepsy (IGE), structural imaging in the baboon is usually normal in individual subjects, but gray matter volume/concentration (GMV/GMC) changes are reported by statistical parametric mapping (SPM) analyses. Functional neuroimaging has been effective for mapping the photoepileptic responses, the epileptic network, altered functional connectivity of physiological networks, and the effects of anti-seizure therapies. This review will provide insights into our current understanding the baboon model of GGE through functional and structural imaging.</jats:p>","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35909685","pmcid":null,"openalex_id":"https://openalex.org/W4285390788","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"1R21NS084198-01A1","title":"Brain MRI and Histopathology of the Epileptic Baboon"},{"funder_name":"National Institutes of Health","grant_id":"1C06RR013556-01","title":"MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATION"},{"funder_name":"National Institutes of Health","grant_id":"1F32NS066694-01A1","title":"Modeling the neuronal activations induced by transcranial magnetic stimulation"},{"funder_name":"National Institutes of Health","grant_id":"3P51OD011133-22S2","title":"Nonhuman Primate model of age-related cognitive decline and dementias"},{"funder_name":"National Institutes of Health","grant_id":"5R21NS065431-02","title":"Multimodal Evaluation of Networks Underlying Photosensitive Epilepsy in Baboons"},{"funder_name":"National Institutes of Health","grant_id":"5R01NS047755-03","title":"Baboon Model for Genetics of Human Generalized Epilepsy"},{"funder_name":"National Institutes of Health","grant_id":"5K01EB006395-04","title":"COMBINING NEUROIMAGING AND GENETICS FOR HERITABILITY MEASUREMENTS"},{"funder_name":"National Institutes of Health","grant_id":"1C06RR014578-01","title":"BABOON F-CAGE FACILITY FOR PRIMATE RESEARCH CENTER"},{"funder_name":"National Institutes of Health","grant_id":"5P51RR013986-13","title":"EARLY MECHANISMS OF HIV TRANSMISSION USING THE SIV/MACAQUE MODEL FOR AIDS"},{"funder_name":"National Institutes of Health","grant_id":"1C06RR015456-01A1","title":"EXTRAMURAL RES FACILITIES CONSTR"}],"total_grants":10,"fwci":0.6448,"citation_percentile":0.59665615,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fvets.2022.908801/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fvets.2022.908801/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fvets.2022.908801/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fvets.2022.908801","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35909685","host_type":"repository"},{"url":"https://doaj.org/article/ca5eeab6c25f4b5f8dffc4ebdebf00d7","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9330034","host_type":"repository"},{"url":"http://dx.doi.org/10.3389/fvets.2022.908801","host_type":""}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Epilepsy research and treatment","Functional Brain Connectivity Studies","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":[],"keywords":["Baboon","Neuroimaging","Neuroscience","Functional neuroimaging","Human brain","Psychology","Brain mapping","Magnetic resonance imaging","Epilepsy","Biology","Medicine","Radiology","genetic generalized epilepsy","PET","General Veterinary","Veterinary medicine","SF600-1100","Veterinary Science","MRI"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T06:10:01.020861Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}