{"doi":"10.3389/frtra.2025.1583919","title":"Long-term outcomes of a case-control lung transplant cohort after SARS-CoV-2 infection","abstract":"Background Respiratory viruses can impact the allograft function in lung transplant recipients, but it is unknown if this occurs with SARS-CoV-2 infection. We studied the long-term outcomes of lung transplant recipients infected with SARS-CoV-2. Methods This single-center retrospective study compared lung transplant recipients with SARS-CoV-2 between June 2020 and April 2021 with a matched control group. Within the SARS-CoV-2 cohort, univariable associations between clinical factors and outcomes were tested. Changes in pulmonary function tests were analyzed. Primary endpoints included acute cellular rejection and all-cause mortality within 12 months. Results Fifty-three lung transplant recipients were infected with SARS-CoV-2. The median age was 64 years. 29 (54.7%) were managed outpatient, and 24 (45.3%) required hospitalization, with 13 intensive care unit admissions. All-cause mortality was 24.5%. Within the SARS-CoV-2 cohort, older age was significantly associated with all-cause mortality ( p -value 0.017) as was ICU admission ( p = 0.009) and an A1C > 6.5 ( p = 0.033). The mean change in FEV1 was −1.1% at 3 months with minimal change at 6 and 12 months (−2.6% and −1% respectively), all compared to baseline. Acute cellular rejection was identified in 13.7% of the SARS-CoV-2 cohort compared to 11.8% in the matched control group; it was not significantly associated with the infection status ( p = 0.706). However, all-cause mortality was significantly associated with infection status ( p = 0.019). Conclusion Long-term outcomes of SARS-CoV-2 in lung transplant recipients are widely variable. Within the SARS-CoV-2 cohort, all-cause mortality was 24.5%, and older age was significantly associated with mortality. We did not observe significant declines in FEV1 in this group.","journal":"Frontiers in Transplantation","year":2025,"id":566481,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9185,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1470558,"name":"Rami Hallak","orcid":null,"position":1,"is_corresponding":false},{"id":1470559,"name":"S.M. Leonard","orcid":null,"position":2,"is_corresponding":false},{"id":982282,"name":"Samantha Morrison","orcid":"0000-0003-0787-8505","position":3,"is_corresponding":false},{"id":380978,"name":"Sarah B. Peskoe","orcid":"0000-0002-1190-3606","position":4,"is_corresponding":false},{"id":1470560,"name":"Jordan Whitson","orcid":null,"position":5,"is_corresponding":false},{"id":380292,"name":"John M. Reynolds","orcid":"0000-0003-4766-8852","position":6,"is_corresponding":false},{"id":104963,"name":"Cameron R. Wolfe","orcid":"0000-0002-5365-5030","position":7,"is_corresponding":false},{"id":951409,"name":"Hakim Azfar Ali","orcid":"0000-0002-8953-7693","position":8,"is_corresponding":false},{"id":1323583,"name":"Sandrine Hanna","orcid":null,"position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-19T02:56:36.440192Z","pmid":"40469640","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}