{"doi":"10.3389/froh.2025.1691158","title":"Correction: Roles of specialized pro-resolving mediators and omega-3 polyunsaturated fatty acids in periodontal inflammation and impact on oral microbiota","abstract":"Roles of specialized pro-resolving mediators and omega-3 polyunsaturated fatty acids in periodontal inflammation and impact on oral microbiota Periodontitis is a chronic inflammatory disease induced by dysbiotic dental biofilms. Management of periodontitis is primarily anti-bacterial via mechanical removal of bacterial biofilm. The successful resolution requires wound healing and tissue regeneration, which are not always achieved with these traditional methods. The discovery of specialized pro-resolving mediators (SPMs), a class of lipid mediators that induce the resolution of inflammation and promote local tissue homeostasis, creates another option for the treatment of periodontitis and other diseases of chronic inflammation. In this mini-review, we discuss the host-modulatory effects of SPMs on periodontal tissues and changes in the taxonomic composition of the gut and oral microbiome in the presence of SPMs and SPM precursor lipids. Further research into the relationship between host SPM production and microbiome-SPM modification has the potential to unveil new diagnostic markers of inflammation and wound healing. Expanding this field may drive the discovery of microbial-derived bioactive therapeutics to modulate immune responses. Epidemiology of periodontitis Oral health is an essential public health issue. Oral diseases cause pain, discomfort, masticatory malfunction, esthetically unacceptable appearance, and overall lower quality of life. Oral health is also highly associated with systemic health. Uncontrolled oral diseases can worsen systemic conditions. According to the 2022 World Health Organization (WHO) Global Oral Health Status Report, oral diseases are estimated to affect approximately 3.5 billion people worldwide, with 3 out of 4 affected people living in middle-income countries. The three most prevalent oral conditions are untreated caries, severe periodontitis, and extensive tooth loss (1). Among the prevalent oral diseases, periodontitis has one of the most complicated mechanisms of pathogenesis. Many researchers are studying its pathogenesis and developing novel diagnostic methods and therapy. Periodontitis is a biofilm-induced chronic inflammatory disease characterized by gingival inflammation and alveolar bone loss around teeth. Untreated periodontitis leads to gingival bleeding, suppuration, pain, and progressive bone loss, eventually causing tooth loss. According to the 2009–2014 National Health and Nutrition Examination Survey (NHANES), in the United States, around 61 million adults over 30 years old have periodontitis (42.2%), with 7.8% TYPE Mini Review PUBLISHED 25 July 2023 | DOI 10.3389/froh.2023.1217088 having severe periodontitis (2). The global cost of lost productivity from severe periodontitis alone was $39 billion yearly, based on 2015 data (1). A recent report demonstrated that periodontal disease generally resulted in indirect and direct costs of $154.06 billion in the United States and €158.64 billion in Europe in 2018 (3). Pathogenesis of periodontitis The disproportionate inflammatory host response and microbiota dysbiosis are the two major etiologic factors in the pathogenesis of periodontitis (4, 5). These two factors do not always exist simultaneously, but they influence each other. The coexistence of these two factors results in the development of periodontitis. A pathogenic biofilm is a prerequisite for periodontitis initiation. Several bacterial species, such as the core red complex species Porphyromonas gingivalis (P. gingivalis), Tannerella forsythia (T.forsythia), and Treponema denticola (T.denticola), are significantly associated with the severity and progression of periodontitis (6). Their virulence factors causing periodontal tissue destruction are also identified. However, these species are usually present in small amounts. The concept of keystone pathogens was proposed (7). The keystone pathogens, such as P. gingivalis, have a relatively small proportion of the overall microb","journal":"Frontiers in Oral Health","year":2025,"id":559117,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":684502,"name":"Gena D. Tribble","orcid":"0000-0002-6468-2851","position":1,"is_corresponding":false},{"id":324047,"name":"Chun‐Teh Lee","orcid":"0000-0001-7812-5637","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:55:30.312295Z","pmid":"41059212","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}