{"doi":"10.3389/frbis.2024.1406868","title":"Unlocking the brain’s zinc code: implications for cognitive function and disease","abstract":"Zn 2+ transport across neuronal membranes relies on two classes of transition metal transporters: the ZnT (SLC30) and ZIP (SLC39) families. These proteins function to decrease and increase cytosolic Zn 2+ levels, respectively. Dysfunction of ZnT and ZIP transporters can alter intracellular Zn 2+ levels resulting in deleterious effects. In neurons, imbalances in Zn 2+ levels have been implicated as risk factors in conditions such as Alzheimer’s disease and neurodegeneration, highlighting the pivotal role of Zn 2+ homeostasis in neuropathologies. In addition, Zn 2+ modulates the function of plasma membrane proteins, including ion channels and receptors. Changes in Zn 2+ levels, on both sides of the plasma membrane, profoundly impact signaling pathways governing cell development, differentiation, and survival. This review is focused on recent developments of neuronal Zn 2+ homeostasis, including the impact of Zn 2+ dyshomeostasis in neurological disorders, therapeutic approaches, and the increasingly recognized role of Zn 2+ as a neurotransmitter in the brain.","journal":"Frontiers in Biophysics","year":2024,"id":427364,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.949,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1228024,"name":"Marzieh Rostamirad","orcid":null,"position":1,"is_corresponding":false},{"id":830370,"name":"Robert E. Dempski","orcid":"0000-0002-7751-1613","position":2,"is_corresponding":false},{"id":1228023,"name":"Soheila Sabouri","orcid":null,"position":0,"is_corresponding":true}],"reference_count":194,"raw_metadata":null,"created_at":"2026-07-19T01:58:47.805440Z","pmid":"39758530","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}