{"doi":"10.3389/fpubh.2024.1419886","title":"Tracking temporal variations of fatality and symptomology correlated with COVID-19 dominant variants and vaccine effectiveness in the United States","abstract":"Introduction: We described how COVID-19 fatality and symptoms varied by dominant variant and vaccination in the US. Methods: Using the Restricted Access Dataset from the US CDC (1/1/2020-10/20/2022), we conducted a cross-sectional study assessing differences in COVID-19 deaths, severity indicators (hospitalization, ICU, pneumonia, abnormal X-ray, acute respiratory distress syndrome, mechanical ventilation) and 12 mild symptoms by dominant variant/vaccination periods using logistic regression after controlling for confounders. Results: We found the highest fatality during the dominant periods of Wild (4.6%) and Delta (3.4%). Most severe symptoms appeared when Delta was dominant (Rate range: 2.0-9.4%). Omicron was associated with higher mild symptoms than other variants. Vaccination showed consistent protection against death and severe symptoms for most variants (Risk Ratio range: 0.41-0.93). Boosters, especially the second, provided additional protection, reducing severe symptoms by over 50%. Discussion: This dataset may serve as a useful tool to monitor temporospatial changes of fatality and symptom for case management and surveillance.","journal":"Frontiers in Public Health","year":2024,"id":461388,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8868,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1289872,"name":"Han Liu","orcid":"0000-0003-4476-2253","position":1,"is_corresponding":false},{"id":1049181,"name":"Quan Qi","orcid":null,"position":2,"is_corresponding":false},{"id":1242492,"name":"Ian Trees","orcid":"0000-0003-4747-6017","position":3,"is_corresponding":false},{"id":875228,"name":"Donghong Gao","orcid":"0000-0001-9638-1546","position":4,"is_corresponding":false},{"id":656948,"name":"Samantha Friedman","orcid":"0000-0002-9402-7241","position":5,"is_corresponding":false},{"id":1290338,"name":"Xiaobo Romeiko Xue","orcid":null,"position":6,"is_corresponding":false},{"id":660467,"name":"David Lawrence","orcid":"0000-0001-5464-5830","position":7,"is_corresponding":false},{"id":725616,"name":"Shao Lin","orcid":"0000-0002-5535-7504","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T02:04:12.271488Z","pmid":"39360263","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}