{"doi":"10.3389/fpsyt.2023.1211516","title":"Hard-to-treat or hard-to-catch? Clinical features and therapeutic outcomes of help-seeking foster care youths with mood disorders","abstract":"<jats:sec><jats:title>Introduction</jats:title><jats:p>The high level of emotional problems in youths placed in foster care contrasts with the limited use of evidence-based treatments. This study aims to better characterize the clinical features and therapeutic outcomes of foster care youths with mood disorders.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A secondary analysis of data collected in the context of a French-Canadian clinical research network on pediatric mood disorders in four sites was conducted to compare three groups of patients with depressive or bipolar disorder: those without exposure to child welfare intervention (WCWI, <jats:italic>n</jats:italic> = 181), those who received non-placement psychosocial intervention (NPI, <jats:italic>n</jats:italic> = 62), and those in placement interventions (PI, <jats:italic>n</jats:italic> = 41).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We observed a very high rate of academic problems in patients in the groups NPI/PI compared to those in the WCWI group. Patients in the PI group had more disruptive behavioral disorders (OR = 6.87, 95% CI [3.25–14.52]), trauma-related disorders (OR = 3.78, 95% CI [1.6–8.94]), and any neurodevelopmental disorders (OR = 2.73, 95% CI [1.36–5.49]) compared to the other groups (NPI/WCWI). Among inpatients, the Clinical Global Impression-Improvement scale and the change in the Children Global Assessment Scale during the hospital stay did not differ across the three groups. We observed a higher prescription rate of antipsychotics in the PI group compared to the NPI/WCWI groups, but no significant difference for antidepressants and mood stabilizers.</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>These findings support the view that, when provided with dedicated support, fostered inpatient youths can improve in a range comparable to other inpatients. Undetected neurodevelopmental disorders and academic problems are likely important contributors of the burden of mood disorders in these youths.</jats:p></jats:sec>","journal":"Frontiers in Psychiatry","year":2023,"id":688199,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1542755,"name":"Hélène Lahaye","orcid":null,"position":1,"is_corresponding":false},{"id":1797850,"name":"Hugues Pellerin","orcid":null,"position":2,"is_corresponding":false},{"id":838603,"name":"Angèle Consoli","orcid":"0000-0003-1357-6538","position":3,"is_corresponding":false},{"id":544121,"name":"David Cohen","orcid":"0000-0002-0320-8865","position":4,"is_corresponding":false},{"id":1797851,"name":"Réal Labelle","orcid":null,"position":5,"is_corresponding":false},{"id":672789,"name":"Johanne Renaud","orcid":"0000-0002-8060-2890","position":6,"is_corresponding":false},{"id":1797852,"name":"Priscille Gérardin","orcid":null,"position":7,"is_corresponding":false},{"id":1797854,"name":"Fabienne El-Khoury","orcid":null,"position":8,"is_corresponding":false},{"id":1477871,"name":"Judith van der Waerden","orcid":"0000-0002-5324-1372","position":9,"is_corresponding":false},{"id":1542757,"name":"Jean-Marc Guilé","orcid":null,"position":10,"is_corresponding":false},{"id":1542758,"name":"Xavier Benarous","orcid":"0000-0003-1994-5779","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Hard-to-treat or hard-to-catch? Clinical features and therapeutic outcomes of help-seeking foster care youths with mood disorders","abstract":"<jats:sec><jats:title>Introduction</jats:title><jats:p>The high level of emotional problems in youths placed in foster care contrasts with the limited use of evidence-based treatments. This study aims to better characterize the clinical features and therapeutic outcomes of foster care youths with mood disorders.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A secondary analysis of data collected in the context of a French-Canadian clinical research network on pediatric mood disorders in four sites was conducted to compare three groups of patients with depressive or bipolar disorder: those without exposure to child welfare intervention (WCWI, <jats:italic>n</jats:italic> = 181), those who received non-placement psychosocial intervention (NPI, <jats:italic>n</jats:italic> = 62), and those in placement interventions (PI, <jats:italic>n</jats:italic> = 41).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We observed a very high rate of academic problems in patients in the groups NPI/PI compared to those in the WCWI group. Patients in the PI group had more disruptive behavioral disorders (OR = 6.87, 95% CI [3.25–14.52]), trauma-related disorders (OR = 3.78, 95% CI [1.6–8.94]), and any neurodevelopmental disorders (OR = 2.73, 95% CI [1.36–5.49]) compared to the other groups (NPI/WCWI). Among inpatients, the Clinical Global Impression-Improvement scale and the change in the Children Global Assessment Scale during the hospital stay did not differ across the three groups. We observed a higher prescription rate of antipsychotics in the PI group compared to the NPI/WCWI groups, but no significant difference for antidepressants and mood stabilizers.</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>These findings support the view that, when provided with dedicated support, fostered inpatient youths can improve in a range comparable to other inpatients. Undetected neurodevelopmental disorders and academic problems are likely important contributors of the burden of mood disorders in these youths.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37900296","pmcid":"PMC10603296","openalex_id":"https://openalex.org/W4387603385","authors":[],"funders":[],"total_grants":0,"fwci":1.057,"citation_percentile":0.81146296,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1211516/pdf?isPublishedV2=False","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1211516/pdf?isPublishedV2=False","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1211516/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fpsyt.2023.1211516","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37900296","host_type":"repository"},{"url":"https://hal.science/hal-04279779","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10603296","host_type":"repository"},{"url":"https://doaj.org/article/38daa968067e4e36a41d8c54d08fbc23","host_type":"repository"},{"url":"https://hal.science/hal-04279779/document","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10603296/pdf/fpsyt-14-1211516.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10603296","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10603296?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Child Welfare and Adoption","Child and Adolescent Psychosocial and Emotional Development","Child Abuse and Trauma"],"mesh_terms":[],"keywords":["Context (archaeology)","Mood","Psychosocial","Intervention (counseling)","Medicine","Global Assessment of Functioning","Mood disorders","Clinical Global Impression","Psychological intervention","Psychiatry","Bipolar disorder","Medical prescription","Clinical psychology","Foster care","Anxiety","Schizophrenia (object-oriented programming)","Alternative medicine","Depressive Disorder","Early-onset Bipolar Disorder","Child Adversity","Disruptive Mood Dysregulation Disorder","Complex Psychotrauma","Adverse Chilhood Experiences","Developmental Psychotrauma"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T13:58:38.983404Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}