{"doi":"10.3389/fpsyt.2022.898003","title":"No association between perinatal mood disorders and hypertensive pregnancies","abstract":"Mental health disorders such as anxiety and/or depression are the most common mental health disorders seen among reproductive aged women and can increase during pregnancy. Many sociodemographic risk factors have been associated with anxiety and/or depression in pregnancy, which can lead to adverse maternal and infant outcomes including the risk of a hypertensive pregnancy. The current study prospectively examined self-reported anxiety, depression and stress in pregnant women without a history of fetal loss or mood disorders beginning at 20-26 weeks. At each study visit, circulating immune factors associated with perinatal mood disorders were measured in blood samples that were collected. A total of 65 women were eligible for data analysis, 26 of which had hypertensive pregnancies. There was not a significant difference in self-reported depression, anxiety or stress between hypertensive disorders of pregnancy and normotensive women. Black women were more likely to have a hypertensive pregnancy and develop a perinatal mood disorder compared to non-black women. Both the inflammatory cytokines interleukin-17 and tumor necrosis factor-alpha were increased in patients with perinatal mood disorders. However, additional research is needed in a larger sample to truly understand the relationship between these factors along with the underlying etiologies and the associated outcomes.","journal":"Frontiers in Psychiatry","year":2022,"id":293190,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9606,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":390351,"name":"Ashley Griffin","orcid":"0009-0003-4583-8165","position":1,"is_corresponding":false},{"id":391208,"name":"Wondwosen Kassahun‐Yimer","orcid":"0000-0002-1272-225X","position":2,"is_corresponding":false},{"id":977607,"name":"Laura J. Dixon","orcid":"0000-0002-9511-2026","position":3,"is_corresponding":false},{"id":391555,"name":"Shauna‐Kay Spencer","orcid":null,"position":4,"is_corresponding":false},{"id":977948,"name":"Sheila Belk","orcid":null,"position":5,"is_corresponding":false},{"id":977608,"name":"Gail Ohaegbulam","orcid":"0000-0002-7869-1134","position":6,"is_corresponding":false},{"id":271719,"name":"Kedra Wallace","orcid":"0000-0003-4511-0046","position":7,"is_corresponding":false},{"id":271720,"name":"Sarah Araji","orcid":"0000-0002-9064-8526","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T00:30:50.076284Z","pmid":"36032225","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}