{"doi":"10.3389/fpsyt.2021.678088","title":"A Systematic Review of Long-Interval Intracortical Inhibition as a Biomarker in Neuropsychiatric Disorders","abstract":"Long-interval intracortical inhibition (LICI) is a paired-pulse transcranial magnetic stimulation (TMS) paradigm mediated in part by gamma-aminobutyric acid receptor B (GABA B ) inhibition. Prior work has examined LICI as a putative biomarker in an array of neuropsychiatric disorders. This review conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) sought to examine existing literature focused on LICI as a biomarker in neuropsychiatric disorders. There were 113 articles that met the inclusion criteria. Existing literature suggests that LICI may have utility as a biomarker of GABA B functioning but more research with increased methodologic rigor is needed. The extant LICI literature has heterogenous methodology and inconsistencies in findings. Existing findings to date are also non-specific to disease. Future research should carefully consider existing methodological weaknesses and implement high-quality test-retest reliability studies.","journal":"Frontiers in Psychiatry","year":2021,"id":178490,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9486,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":724248,"name":"Mehmet Utku Küçüker","orcid":"0000-0002-3508-5935","position":1,"is_corresponding":false},{"id":724249,"name":"Jennifer L. Vande Voort","orcid":"0000-0002-3630-4773","position":2,"is_corresponding":false},{"id":725050,"name":"Deniz Doruk Camsari","orcid":null,"position":3,"is_corresponding":false},{"id":333476,"name":"Faranak Farzan","orcid":"0000-0001-9249-2994","position":4,"is_corresponding":false},{"id":294680,"name":"Paul E. Croarkin","orcid":"0000-0001-6843-6503","position":5,"is_corresponding":false},{"id":724247,"name":"Parmis Fatih","orcid":"0000-0001-9608-1834","position":0,"is_corresponding":true}],"reference_count":170,"raw_metadata":null,"created_at":"2026-07-18T23:47:40.592580Z","pmid":"34149483","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}