{"doi":"10.3389/fphys.2024.1508729","title":"Editorial: Molecular mechanisms of lung endothelial permeability, vol II","abstract":"The interplay of extracellular vehicles (EVs), endothelial cell responses, and signaling pathways presents a complex picture of the mechanisms underlying acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). These severe respiratory conditions, complicated by intricate pathogenesis, highlight the role of EVs in mediating intercellular communication and represent potential for novel therapeutic approaches. In their study for the current Research Topic, Karpurapu et al. reported that EVs are crucial in transporting biologically active macromolecules between cells, particularly in the lungs. In mouse models, the activation of nuclear factor of activated T cell cytoplasmic member 3 (NFATc3) in pulmonary macrophages in response to lipopolysaccharide (LPS) has been observed. The inhibition of this activation by a novel cellpermeable calcineurin peptide inhibitor, CNI103, effectively mitigates the symptoms of ALI. EVs from the bronchoalveolar lavage fluid of LPS-treated mice contain elevated levels of arachidonic acid metabolites, directly implicating pro-inflammatory lipid mediators in lung inflammation and injury. This discovery points to a regulatory mechanism where the calcineurin-NFATc3 pathway influences the lipid content of EVs, impacting the pathogenesis of ALI. The purinergic signaling system is emerging as a critical regulatory circuit, essential for maintaining homeostatic balance and modulating pathological vascular responses in various cardiovascular and lung diseases. Despite its recognized significance, investigations into purinergic regulation specifically within the lung endothelium and vasa vasorum endothelium","journal":"Frontiers in Physiology","year":2024,"id":505149,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1125983,"name":"Rahul Patil","orcid":"0000-0003-2447-2355","position":1,"is_corresponding":false},{"id":441754,"name":"Narasimham L. Parinandi","orcid":"0000-0003-3489-0286","position":2,"is_corresponding":false},{"id":404912,"name":"Evgenia Gerasimovskaya","orcid":"0000-0003-1256-7699","position":3,"is_corresponding":false},{"id":430450,"name":"Alexander D. Verin","orcid":"0000-0003-0627-7185","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:10:43.302033Z","pmid":"39502407","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}